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Journal Articles

IL-6 trans-signaling is increased in diabetes, impacted by glucolipotoxicity and associated with liver stiffness and fibrosis in fatty liver disease

Aysim Gunes, Clémence Schmitt, Laurent Bilodeau, Catherine Huet, Assia Belblidia, Cindy Baldwin, Jeanne-Marie Giard, Laurent Biertho, Annie Lafortune, Christian Yves Couture, Angela Cheung, Bich N Nguyen, Eithan Galun, Chantal Bémeur, Marc Bilodeau, Mathieu Laplante, An Tang, May Faraj, Jennifer L. Estall

Diabetes db230171

https://doi.org/10.2337/db23-0171

Published: 27 September 2023

View article titled, IL-6 trans-signaling is increased in diabetes, impacted by glucolipotoxicity and associated with liver stiffness and fibrosis in fatty liver disease

Journal Articles

Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling

Guanlan Xu, Junqin Chen, Brian Lu, Praveen Sethupathy, Wei-Jun Qian, Anath Shalev

Diabetes 2023;72(10):1460–1469

https://doi.org/10.2337/db23-0256

Published: 26 July 2023

View article titled, Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling

Journal Articles

Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

Paul Sohn, Madeline R. McLaughlin, Preethi Krishnan, Wenting Wu, Marjan Slak Rupnik, Akira Takasu, Toshiya Senda, Chih-Chun Lee, Tatsuyoshi Kono, Carmella Evans-Molina

Diabetes 2023;72(10):1433–1445

https://doi.org/10.2337/db22-0988

Published: 21 July 2023

View article titled, Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

Meeting Abstracts

1780-P: Assessment of Toll-Like Receptor Expression and Signaling in Islets under Metabolic and Inflammatory Conditions

JORDAN D. MATTKE, BASHOO NAZIRUDDIN, MICHAEL C. LAWRENCE

Diabetes 2023;72(Supplement_1):1780-P

https://doi.org/10.2337/db23-1780-P

Published: 20 June 2023

View article titled, 1780-P: Assessment of Toll-Like Receptor Expression and Signaling in Islets under Metabolic and Inflammatory Conditions

Meeting Abstracts

1778-P: Endoplasmic Reticulum Stress Leads to Pancreatic Beta-Cell Failure by Suppressing cAMP Signaling via ATF4

JAEMIN LEE

Diabetes 2023;72(Supplement_1):1778-P

https://doi.org/10.2337/db23-1778-P

Published: 20 June 2023

View article titled, 1778-P: Endoplasmic Reticulum Stress Leads to Pancreatic Beta-Cell Failure by Suppressing cAMP Signaling via ATF4

Meeting Abstracts

1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

JARED I. SENFELD, MATTHEW LYNES, SEAN KODANI, KIN SING STEPHEN LEE, YU-HUA TSENG

Diabetes 2023;72(Supplement_1):1650-P

https://doi.org/10.2337/db23-1650-P

Published: 20 June 2023

View article titled, 1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

Meeting Abstracts

1536-P: Effects of Sucralose vs. Sucrose on Hypothalamic Blood Flow, Glucose Signaling, and Appetite

SANDHYA P. CHAKRAVARTTI, STEPHANIE KULLMANN, RALF VEIT, ALEXANDRA G. YUNKER, BRENDAN C. ANGELO, KAY JANN, SHAN H. LUO, ANNY XIANG, JOHN R. MONTEROSSO, KATHLEEN A. PAGE

Diabetes 2023;72(Supplement_1):1536-P

https://doi.org/10.2337/db23-1536-P

Published: 20 June 2023

View article titled, 1536-P: Effects of Sucralose vs. Sucrose on Hypothalamic Blood Flow, Glucose Signaling, and Appetite

Meeting Abstracts

1531-P: Preoptic Anterior Hypothalamus Estrogen Signaling Controls Energy and Temperature Homeostasis

PEI LUO, XIAOHUA YANG, BING FENG, HUI YE, NIMISHA ANTONY, LESLIE CARRILLO-SÁENZ, VALERIA C. TORRES IRIZARRY, BRIAN T. LAYDEN, YANLIN HE, PINGWEN XU

Diabetes 2023;72(Supplement_1):1531-P

https://doi.org/10.2337/db23-1531-P

Published: 20 June 2023

View article titled, 1531-P: Preoptic Anterior Hypothalamus Estrogen Signaling Controls Energy and Temperature Homeostasis

Meeting Abstracts

1528-P: Hypothalamic SEL1L-HRD1 ER–Associated Degradation Is Indispensable for Leptin Signaling in Diet-Induced Obesity by Degrading Misfolded Leptin Receptor

HANCHENG MAO, LING QI

Diabetes 2023;72(Supplement_1):1528-P

https://doi.org/10.2337/db23-1528-P

Published: 20 June 2023

View article titled, 1528-P: Hypothalamic SEL1L-HRD1 ER–Associated Degradation Is Indispensable for Leptin Signaling in Diet-Induced Obesity by Degrading Misfolded Leptin Receptor

Meeting Abstracts

1512-P: The Novel Roles of Intracellular Calcium and Phosphoinositides in Insulin Signaling and Metabolic Disease

JIN-WOOK LEE, YUNJAE JUNG, SEUNG-SOON IM, DAE HO LEE, HWA-YONG LEE, IN SUN HONG, OK-HEE KIM, BYUNG-CHUL OH

Diabetes 2023;72(Supplement_1):1512-P

https://doi.org/10.2337/db23-1512-P

Published: 20 June 2023

View article titled, 1512-P: The Novel Roles of Intracellular Calcium and Phosphoinositides in Insulin Signaling and Metabolic Disease

Meeting Abstracts

1511-P: Identifying How Endothelial Protease-Activated Receptors Control Insulin Signaling—Implications for Diabetes

RAHUL RAJALA, COURTNEY GRIFFIN

Diabetes 2023;72(Supplement_1):1511-P

https://doi.org/10.2337/db23-1511-P

Published: 20 June 2023

View article titled, 1511-P: Identifying How Endothelial Protease-Activated Receptors Control Insulin Signaling—Implications for Diabetes

Meeting Abstracts

774-P: Weight-Independent Effects of CT-868, a Signaling Biased Dual GLP-1/GIP Receptor Modulator, on Glucose Homeostasis in Overweight and Obese Adults with Type 2 Diabetes

MANU CHAKRAVARTHY, MOISES HERNANDEZ, MICHAEL ELLIOTT, ALEJANDRA MACIAS, STIG K. HANSEN, MARCUS HOMPESCH

Diabetes 2023;72(Supplement_1):774-P

https://doi.org/10.2337/db23-774-P

Published: 20 June 2023

View article titled, 774-P: Weight-Independent Effects of CT-868, a Signaling Biased Dual GLP-1/GIP Receptor Modulator, on Glucose Homeostasis in Overweight and Obese Adults with Type 2 Diabetes

Meeting Abstracts

189-OR: FGF21-Mediated Signaling Defects and Their Effects on Insulin Resistance in Insulin-Mediated Pseudoacromegaly

NHUNG PHAN, DAVID M. ORNITZ, STEPHEN I. STONE

Diabetes 2023;72(Supplement_1):189-OR

https://doi.org/10.2337/db23-189-OR

Published: 20 June 2023

View article titled, 189-OR: FGF21-Mediated Signaling Defects and Their Effects on Insulin Resistance in Insulin-Mediated Pseudoacromegaly

Meeting Abstracts

232-OR: STIM1 Interacts with G Protein–Coupled Estrogen Receptor Signaling to Maintain ß-Cell Identity in Female Mice

MADELINE MCLAUGHLIN, PAUL SOHN, PREETHI KRISHNAN, CHIH-CHUN LEE, TATSUYOSHI KONO, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):232-OR

https://doi.org/10.2337/db23-232-OR

Published: 20 June 2023

View article titled, 232-OR: STIM1 Interacts with G Protein–Coupled Estrogen Receptor Signaling to Maintain ß-Cell Identity in Female Mice

Meeting Abstracts

232-LB: Transcriptional Regulation of Adipocyte Insulin and Inflammatory Signaling by Early B-Cell Factor-1 (Ebf1)

ALEX GUTIERREZ, YADIRA MARTINEZ, KIMBERLY IBARRA, ZACHARY BAILEY, MICHAEL GRIFFIN

Diabetes 2023;72(Supplement_1):232-LB

https://doi.org/10.2337/db23-232-LB

Published: 20 June 2023

View article titled, 232-LB: Transcriptional Regulation of Adipocyte Insulin and Inflammatory Signaling by Early B-Cell Factor-1 (Ebf1)

Meeting Abstracts

308-OR: Hippo-YAP/TAZ Signaling Coordinates Adipose Plasticity and Energy Balance by Uncoupling Leptin Expression from Fat Mass

SUNGWOO CHOI, KUN-YOUNG PARK, HYEMI SHIN, JAE MYOUNG SUH

Diabetes 2023;72(Supplement_1):308-OR

https://doi.org/10.2337/db23-308-OR

Published: 20 June 2023

View article titled, 308-OR: Hippo-YAP/TAZ Signaling Coordinates Adipose Plasticity and Energy Balance by Uncoupling Leptin Expression from Fat Mass

Meeting Abstracts

301-OR: Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation

VALERIA C. TORRES IRIZARRY, HUI YE, PEI LUO, LESLIE CARRILLO-SÁENZ, XIAOHUA YANG, MARCOS D. MUNOZ, NIMISHA ANTONY, YUWEI JIANG, YANLIN HE, PINGWEN XU

Diabetes 2023;72(Supplement_1):301-OR

https://doi.org/10.2337/db23-301-OR

Published: 20 June 2023

View article titled, 301-OR: Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation

Meeting Abstracts

1686-P: ER Stress Aggravates Diaphragmatic Weakness through Activating PERK/JNK Signaling in Obesity Hypoventilation Syndrome

XIAOXIN XIANG, YANHUA ZHU, XUYA PAN, WEI XIN, WEIJIAN TANG, XUEMIN HE, GUOJUN SHI, YANMING CHEN

Diabetes 2023;72(Supplement_1):1686-P

https://doi.org/10.2337/db23-1686-P

Published: 20 June 2023

View article titled, 1686-P: ER Stress Aggravates Diaphragmatic Weakness through Activating PERK/JNK Signaling in Obesity Hypoventilation Syndrome

Meeting Abstracts

240-LB: Unrestrained Sympathetic Signaling Is a Key Driver of Obesity-Induced Insulin Resistance

KENICHI SAKAMOTO, GIULIA MAURIZI, BANDY CHEN, ADHAM SHAWKAT, LIKHITHA PATLOLLA, AZEDDINE TAHIRI, ALICE BUTERA, CHRISTOPH BUETTNER

Diabetes 2023;72(Supplement_1):240-LB

https://doi.org/10.2337/db23-240-LB

Published: 20 June 2023

View article titled, 240-LB: Unrestrained Sympathetic Signaling Is a Key Driver of Obesity-Induced Insulin Resistance

Meeting Abstracts

1593-P: Insulin-Degrading Enzyme (IDE) Regulates Glucagon Signalling and Mitochondrial Respiration in Hepatocytes

CARLOS M. GONZÁLEZ-CASIMIRO, PATRICIA CÁMARA-TORRES, BEATRIZ MERINO, JAIME SANTO-DOMINGO, MIGUEL A. DE LA FUENTE, ANDRÉS ALONSO, IRENE COZAR-CASTELLANO, GERMAN PERDOMO

Diabetes 2023;72(Supplement_1):1593-P

https://doi.org/10.2337/db23-1593-P

Published: 20 June 2023

View article titled, 1593-P: Insulin-Degrading Enzyme (IDE) Regulates Glucagon Signalling and Mitochondrial Respiration in Hepatocytes

NARROW

IL-6 trans-signaling is increased in diabetes, impacted by glucolipotoxicity and associated with liver stiffness and fibrosis in fatty liver disease

Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling

Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

1780-P: Assessment of Toll-Like Receptor Expression and Signaling in Islets under Metabolic and Inflammatory Conditions

1778-P: Endoplasmic Reticulum Stress Leads to Pancreatic Beta-Cell Failure by Suppressing cAMP Signaling via ATF4

1650-P: Characterizing the Mechanism of Action of the Lipokine 12,13-diHOME

1536-P: Effects of Sucralose vs. Sucrose on Hypothalamic Blood Flow, Glucose Signaling, and Appetite

1531-P: Preoptic Anterior Hypothalamus Estrogen Signaling Controls Energy and Temperature Homeostasis

1528-P: Hypothalamic SEL1L-HRD1 ER–Associated Degradation Is Indispensable for Leptin Signaling in Diet-Induced Obesity by Degrading Misfolded Leptin Receptor

1512-P: The Novel Roles of Intracellular Calcium and Phosphoinositides in Insulin Signaling and Metabolic Disease

1511-P: Identifying How Endothelial Protease-Activated Receptors Control Insulin Signaling—Implications for Diabetes

774-P: Weight-Independent Effects of CT-868, a Signaling Biased Dual GLP-1/GIP Receptor Modulator, on Glucose Homeostasis in Overweight and Obese Adults with Type 2 Diabetes

189-OR: FGF21-Mediated Signaling Defects and Their Effects on Insulin Resistance in Insulin-Mediated Pseudoacromegaly

232-OR: STIM1 Interacts with G Protein–Coupled Estrogen Receptor Signaling to Maintain ß-Cell Identity in Female Mice

232-LB: Transcriptional Regulation of Adipocyte Insulin and Inflammatory Signaling by Early B-Cell Factor-1 (Ebf1)

308-OR: Hippo-YAP/TAZ Signaling Coordinates Adipose Plasticity and Energy Balance by Uncoupling Leptin Expression from Fat Mass

301-OR: Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation

1686-P: ER Stress Aggravates Diaphragmatic Weakness through Activating PERK/JNK Signaling in Obesity Hypoventilation Syndrome

240-LB: Unrestrained Sympathetic Signaling Is a Key Driver of Obesity-Induced Insulin Resistance

1593-P: Insulin-Degrading Enzyme (IDE) Regulates Glucagon Signalling and Mitochondrial Respiration in Hepatocytes

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