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Meeting Abstracts

1702-P: Altered Gene Expression Signatures following COVID-19 Infections and/or mRNA Vaccination in Human Adipose Tissue

SONTJE KRUPKA, MATTHIAS BLÜHER, NORA KLÖTING
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1702-P
https://doi.org/10.2337/db23-1702-P
Published: 20 June 2023
View article titled, 1702-P: Altered Gene Expression Signatures following COVID-19 Infections and/or mRNA Vaccination in Human Adipose Tissue
Meeting Abstracts

33-OR: Epigenetic Reader BRD4 Directs Fast-Twitch Myofiber Gene Programs Influencing Skeletal Muscle Endurance Capacity and Systemic Glucose Homeostasis

ZHENG ZHOU, LIN LIU, ZHISHENG XU, TINGTING FU, LIKUN YANG, MAO YAN, ZHENJI GAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):33-OR
https://doi.org/10.2337/db23-33-OR
Published: 20 June 2023
View article titled, 33-OR: Epigenetic Reader BRD4 Directs Fast-Twitch Myofiber Gene Programs Influencing Skeletal Muscle Endurance Capacity and Systemic Glucose Homeostasis
Meeting Abstracts

1177-P: Maternal Insulin Intervention Improves Offspring Glucose Metabolism via Long Noncoding RNA

QIAN ZHANG, XINHUA XIAO, MING LI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1177-P
https://doi.org/10.2337/db23-1177-P
Published: 20 June 2023
View article titled, 1177-P: Maternal Insulin Intervention Improves Offspring Glucose Metabolism via Long Noncoding RNA
Meeting Abstracts

1175-P: The Alteration of Serum Level and Expression of c-MET in Gestational Diabetes Mellitus (GDM)

HYUN JIN KIM, JUHEE LEE, YE WON JUNG, MINA LEE, JIMIN KIM, KYONG HYE JOUNG, BON JEONG KU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1175-P
https://doi.org/10.2337/db23-1175-P
Published: 20 June 2023
View article titled, 1175-P: The Alteration of Serum Level and Expression of c-MET in Gestational Diabetes Mellitus (GDM)
Meeting Abstracts

1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets

KATIE C. COATE, XIN TONG, JIN-HUA LIU, REGINA JENKINS, RADHIKA ARAMANDLA, NANDITA DEY, SEUNG KIM, MARCELA BRISSOVA, ALVIN C. POWERS, ROLAND STEIN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1742-P
https://doi.org/10.2337/db23-1742-P
Published: 20 June 2023
View article titled, 1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets
Meeting Abstracts

596-P: Exercise Increases Plasma Neuronal Growth Regulator 1 (NEGR1) Concentrations in Human Subjects

PASQUALE NIGRO, NICHOLAS P. CARBONE, CARLOS BUENO JUNIOR, MARIA VAMVINI, LAURA SIMPSON, GEORGIA A. HANSBURY, MICHAEL F. HIRSHMAN, ROELAND J.W. MIDDELBEEK, LAURIE GOODYEAR
Journal: Diabetes
Diabetes 2023;72(Supplement_1):596-P
https://doi.org/10.2337/db23-596-P
Published: 20 June 2023
View article titled, 596-P: Exercise Increases Plasma Neuronal Growth Regulator 1 (NEGR1) Concentrations in Human Subjects
Meeting Abstracts

363-OR: Brown Adipose Tissue m6A mRNA Methylation Regulates Systemic Insulin Sensitivity via a Prostaglandin Interorgan Axis

LING XIAO, DARIO F. DE JESUS, CHENG-WEI JU, JIANGBO WEI, JIANG HU, TADATAKA TSUJI, CHERYL CERO, DOROTA KAMINSKA, AARON M. CYPESS, JUSSI PIHLAJAMAKI, YU-HUA TSENG, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):363-OR
https://doi.org/10.2337/db23-363-OR
Published: 20 June 2023
View article titled, 363-OR: Brown Adipose Tissue m6A mRNA Methylation Regulates Systemic Insulin Sensitivity via a Prostaglandin Interorgan Axis
Journal Articles

Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity

Renxiang Xie, Sujun Yan, Xiaoling Zhou, Yunyi Gao, Yu Qian, Jingyu Hou, Zhanghui Chen, Kairan Lai, Xiangwei Gao, Saisai Wei
Journal: Diabetes
Diabetes 2023;72(8):1083–1094
https://doi.org/10.2337/db22-0775
Published: 24 May 2023
View article titled, Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity
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Journal Articles

PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ

Yi Zhong, Yilong Wang, Xiaoguang Li, Haojie Qin, Shu Yan, Caijun Rao, Di Fan, Duqiu Liu, Fei Deng, Yanli Miao, Ling Yang, Kai Huang
Journal: Diabetes
Diabetes 2023;72(8):1095–1111
https://doi.org/10.2337/db22-1016
Published: 22 May 2023
View article titled, PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
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Journal Articles

Long Noncoding RNA PPT2-EGFL8 Regulates Pathological Retinal Neovascularization in PDR by Functioning as a Competing Endogenous RNA

Zifan Xu, Jiahui Yang, Haohan Zheng, Tianhua Xie, Qian Yang, Jiping Cai, Chao Sun, Yujuan Cao, Meili Wu, Yanqiu Liu, Yuqing Cui, Yong Yao, Xiaolu Wang
Journal: Diabetes
Diabetes 2023;72(7):1012–1027
https://doi.org/10.2337/db22-0342
Published: 21 April 2023
View article titled, Long Noncoding RNA PPT2-EGFL8 Regulates Pathological Retinal Neovascularization in PDR by Functioning as a Competing Endogenous RNA
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Journal Articles

Subendothelial Matrix Stiffening by Lysyl Oxidase Enhances RAGE-Mediated Retinal Endothelial Activation in Diabetes

Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Nikolaos Matisioudis, Timothy S. Kern, Kaustabh Ghosh
Journal: Diabetes
Diabetes 2023;72(7):973–985
https://doi.org/10.2337/db22-0761
Published: 14 April 2023
View article titled, Subendothelial Matrix Stiffening by Lysyl Oxidase Enhances RAGE-Mediated Retinal Endothelial Activation in Diabetes
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Journal Articles

Adipocyte Thyroid Hormone β Receptor–Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and Systemic Homeostasis

Yiruo Ma, Siyi Shen, Ying Yan, Shengjie Zhang, Shengnan Liu, Zhili Tang, Jing Yu, Mei Ma, Zhoumin Niu, Zhuoyang Li, Yuting Wu, Lin Zhao, Zhiqiang Lu, Chunchun Wei, Weiping J. Zhang, Ying Xue, Qiwei Zhai, Yu Li, Cheng Hu, Jingjing Jiang, Yuying Li, Hao Ying
Journal: Diabetes
Diabetes 2023;72(5):562–574
https://doi.org/10.2337/db22-0656
Published: 01 February 2023
View article titled, Adipocyte Thyroid Hormone β Receptor–Mediated Hormone Action Fine-tunes Intracellular Glucose and Lipid Metabolism and Systemic Homeostasis
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Journal Articles

Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes

Sevda Gheibi, Luis Rodrigo Cataldo, Alexander Hamilton, Mi Huang, Sebastian Kalamajski, Malin Fex, Hindrik Mulder
Journal: Diabetes
Diabetes 2023;72(4):455–466
https://doi.org/10.2337/db22-0472
Published: 20 January 2023
View article titled, Reduced Expression Level of Protein Phosphatase <em>PPM1E</em> Serves to Maintain Insulin Secretion in Type 2 Diabetes
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Journal Articles

VEGF-A: A Novel Mechanistic Link Between CYP2C-Derived EETs and Nox4 in Diabetic Kidney Disease

Rachel Njeim, Kawthar Braych, Hilda E. Ghadieh, Nadim S. Azar, William S. Azar, Batoul Dia, Angelo Leone, Francesco Cappello, Hala Kfoury, Frederic Harb, Abdo R. Jurjus, Assaad A. Eid, Fuad N. Ziyadeh
Journal: Diabetes
Diabetes 2023;72(7):947–957
https://doi.org/10.2337/db22-0636
Published: 20 January 2023
View article titled, VEGF-A: A Novel Mechanistic Link Between CYP2C-Derived EETs and Nox4 in Diabetic Kidney Disease
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Journal Articles

Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage

Laura Regué, William Wang, Fei Ji, Joseph Avruch, Hua Wang, Ning Dai
Journal: Diabetes
Diabetes 2023;72(1):33–44
https://doi.org/10.2337/db21-1087
Published: 11 October 2022
View article titled, Human T2D-Associated Gene <em>IMP2/IGF2BP2</em> Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage
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Journal Articles

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

Chieh Min Jamie Chu, Honey Modi, Cara Ellis, Nicole A.J. Krentz, Søs Skovsø, Yiwei Bernie Zhao, Haoning Cen, Nilou Noursadeghi, Evgeniy Panzhinskiy, Xiaoke Hu, Derek A. Dionne, Yi Han Xia, Shouhong Xuan, Mark O. Huising, Timothy J. Kieffer, Francis C. Lynn, James D. Johnson
Journal: Diabetes
Diabetes 2022;71(12):2612–2631
https://doi.org/10.2337/db21-1065
Published: 28 September 2022
View article titled, Dynamic <em>Ins2</em> Gene Activity Defines β-Cell Maturity States
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Journal Articles

TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling

Hwan Hee Lee, Gyu Won Jeong, Byeong Jin Ye, Eun Jin Yoo, Keoung Sun Son, Dong Ki Kim, Hye-Kyung Park, Byoung Heon Kang, Whaseon Lee-Kwon, Hyug Moo Kwon, Soo Youn Choi
Journal: Diabetes
Diabetes 2022;71(12):2557–2571
https://doi.org/10.2337/db21-1099
Published: 28 September 2022
View article titled, TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling
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Journal Articles

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice

Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
Journal: Diabetes
Diabetes 2022;71(11):2412–2425
https://doi.org/10.2337/db22-0402
Published: 19 August 2022
View article titled, REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
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Journal Articles

Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis

Xuan Shen, Yajun Zhang, Xuetao Ji, Bo Li, Yuzhu Wang, Yun Huang, Xu Zhang, Jingxian Yu, Ruihan Zou, Dongdong Qin, Hongwen Zhou, Qian Wang, John Zhong Li
Journal: Diabetes
Diabetes 2022;71(9):1915–1928
https://doi.org/10.2337/db21-1145
Published: 30 June 2022
View article titled, Long Noncoding RNA lncRHPL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis
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Meeting Abstracts

204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo

REBECCA K. DAVIDSON, NOLAN CASEY, SUKRATI KANOJIA, JASON SPAETH
Journal: Diabetes
Diabetes 2022;71(Supplement_1):204-OR
https://doi.org/10.2337/db22-204-OR
Published: 01 June 2022
View article titled, 204-OR: The Chd4 Helicase Modulates ß-Cell Function In Vivo