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Meeting Abstracts

10-OR: The Triple Roles of Tubular Mitochondria AKT in the Regulation of Renal Function, Insulin Resistance, and Body Composition during Development of Diabetic Nephropathy

ESAM SALEM, ALBERT TA, HUGO Y.H. LIN, JUNFENG LI, PING H. WANG

Diabetes 2023;72(Supplement_1):10-OR

https://doi.org/10.2337/db23-10-OR

Published: 20 June 2023

View article titled, 10-OR: The Triple Roles of Tubular Mitochondria AKT in the Regulation of Renal Function, Insulin Resistance, and Body Composition during Development of Diabetic Nephropathy

Journal Articles

Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Teayoun Kim, Shelly Nason, Jessica Antipenko, Brian Finan, Anath Shalev, Richard DiMarchi, Kirk M. Habegger

Diabetes 2022;71(10):2123–2135

https://doi.org/10.2337/db21-1018

Published: 25 July 2022

View article titled, Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Meeting Abstracts

1303-P: Decreased Hepatic HMGB1 in Type 2 Diabetes Increases Mitochondrial Glucose Uptake by Regulating Insulin/AKT Signaling

ZEYU LIU, CHRISTOF KALTENMEIER, ROBERTO I. MOTA ALVIDREZ

Diabetes 2022;71(Supplement_1):1303-P

https://doi.org/10.2337/db22-1303-P

Published: 01 June 2022

View article titled, 1303-P: Decreased Hepatic HMGB1 in Type 2 Diabetes Increases Mitochondrial Glucose Uptake by Regulating Insulin/AKT Signaling

Meeting Abstracts

1378-P: Chronic Sleep Deprivation Impaired Bone Formation in Growing Rats and Downregulated PI3K/AKT Signaling in Bone Tissues

XIAOYE DUAN, LIXIN GUO

Diabetes 2022;71(Supplement_1):1378-P

https://doi.org/10.2337/db22-1378-P

Published: 01 June 2022

View article titled, 1378-P: Chronic Sleep Deprivation Impaired Bone Formation in Growing Rats and Downregulated PI3K/AKT Signaling in Bone Tissues

Journal Articles

Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination

Yuguo Niu, Haizhou Jiang, Hanrui Yin, Fenfen Wang, Ronggui Hu, Xiaoming Hu, Bo Peng, Yousheng Shu, Zhigang Li, Shanghai Chen, Feifan Guo

Diabetes 2022;71(5):921–933

https://doi.org/10.2337/db21-0857

Published: 22 February 2022

View article titled, Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination

Journal Articles

Statement of Retraction. Christopher Lipina, Clare Stretton, Simon Hastings, Jonathan S. Hundal, Ken Mackie, Andrew J. Irving, and Harinder S. Hundal. Regulation of MAP Kinase–Directed Mitogenic and Protein Kinase B–Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells. Diabetes 2010;59: 375–385 . DOI: 10.2337/db09-0979 . PMID: 19933999. PMCID: PMC2809953

American Diabetes Association

Diabetes 2021;70(8):1910

https://doi.org/10.2337/db21-rt08a

Published: 13 August 2021

View article titled, Statement of Retraction. Christopher Lipina, Clare Stretton, Simon Hastings, Jonathan S. Hundal, Ken Mackie, Andrew J. Irving, and Harinder S. Hundal. Regulation of MAP Kinase–Directed Mitogenic and Protein Kinase B–Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells. Diabetes 2010;59: 375–385 . DOI: 10.2337/db09-0979 . PMID: 19933999. PMCID: PMC2809953

Meeting Abstracts

29-LB: Exercise Effects on ?3-AMPK Activity, Akt Substrate of 160 kDa Phosphorylation, and Glucose Uptake in Muscle of Normal and Insulin-Resistant Female Rats

HAIYAN WANG, EDWARD B. ARIAS, AMY ZHENG, SEONGEUN KWAK, JIAHUI ZHAO, GENGFU DONG, GREGORY D. CARTEE

Diabetes 2021;70(Supplement_1):29-LB

https://doi.org/10.2337/db21-29-LB

Published: 01 June 2021

View article titled, 29-LB: Exercise Effects on ?3-AMPK Activity, Akt Substrate of 160 kDa Phosphorylation, and Glucose Uptake in Muscle of Normal and Insulin-Resistant Female Rats

Meeting Abstracts

178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

TRACY K. HER, MATTHEW BROWN, ALEKSEY MATVEYENKO, NAUREEN JAVEED

Diabetes 2021;70(Supplement_1):178-OR

https://doi.org/10.2337/db21-178-OR

Published: 01 June 2021

View article titled, 178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

Meeting Abstracts

121-OR: Activation of FoxO1 Induces Akt Phosphorylation and Mimics the Metabolic Functions of Insulin without Proliferative Effects on 3T3-L1 Adipocytes

TOMOHIRO OHNO, HIRAKU ONO, KENJI TAKEDA, KOUTARO YOKOTE

Diabetes 2021;70(Supplement_1):121-OR

https://doi.org/10.2337/db21-121-OR

Published: 01 June 2021

View article titled, 121-OR: Activation of FoxO1 Induces Akt Phosphorylation and Mimics the Metabolic Functions of Insulin without Proliferative Effects on 3T3-L1 Adipocytes

Journal Articles

WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2

Luyao Zhang, Xue Li, Nan Zhang, Xin Yang, Tianyun Hou, Wan Fu, Fengjie Yuan, Lina Wang, He Wen, Yuan Tian, Hongquan Zhang, Xifeng Lu, Wei-Guo Zhu

Diabetes 2020;69(9):1887–1902

https://doi.org/10.2337/db19-0699

Published: 08 July 2020

View article titled, WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2

Meeting Abstracts

1699-P: Mechanisms and Roles of Foxo1-Akt Negative Feedback Pathway in Adipocytes

TOMOHIRO OHNO, HIRAKU ONO, KOUTARO YOKOTE

Diabetes 2020;69(Supplement_1):1699-P

https://doi.org/10.2337/db20-1699-P

Published: 01 June 2020

View article titled, 1699-P: Mechanisms and Roles of Foxo1-Akt Negative Feedback Pathway in Adipocytes

Meeting Abstracts

1108-P: Resveratrol Inhibits Dapagliflozin-Induced Renal Gluconeogenesis through Modulating the PI3k/Akt/Foxo1 Pathway in HK-2 Cells

XIAOYA SUN

Diabetes 2020;69(Supplement_1):1108-P

https://doi.org/10.2337/db20-1108-P

Published: 01 June 2020

View article titled, 1108-P: Resveratrol Inhibits Dapagliflozin-Induced Renal Gluconeogenesis through Modulating the PI3k/Akt/Foxo1 Pathway in HK-2 Cells

Meeting Abstracts

261-OR: CDK4-R24C Compensates for IRS2 Deficiency by Enhancing Beta-Cell Proliferation and Restoring Signaling through the AKT-Foxo1-PDX1 Pathway

RACHEL E. STAMATERIS, ROHIT B. SHARMA, BRIAN GABLASKI, SUSHIL G. RANE, LAURA C. ALONSO

Diabetes 2020;69(Supplement_1):261-OR

https://doi.org/10.2337/db20-261-OR

Published: 01 June 2020

View article titled, 261-OR: CDK4-R24C Compensates for IRS2 Deficiency by Enhancing Beta-Cell Proliferation and Restoring Signaling through the AKT-Foxo1-PDX1 Pathway

Meeting Abstracts

1806-P: Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis

QI YUAN, JINGLEI YANG, MENGYUE SUN, SHAN TANG, MEIJUAN DONG, LI MAO

Diabetes 2020;69(Supplement_1):1806-P

https://doi.org/10.2337/db20-1806-P

Published: 01 June 2020

View article titled, 1806-P: Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis

Journal Articles

Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

Huishou Zhao, Fuyang Zhang, Dan Sun, Xiong Wang, Xiaomeng Zhang, Jinglong Zhang, Feng Yan, Chong Huang, Huaning Xie, Chen Lin, Yi Liu, Miaomiao Fan, Wenjun Yan, Youhu Chen, Kun Lian, Yueyang Li, Ling Zhang, Shan Wang, Ling Tao

Diabetes 2020;69(6):1164–1177

https://doi.org/10.2337/db19-0920

Published: 17 March 2020

View article titled, Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

Journal Articles

A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action

Dorte E. Steenberg, Janne R. Hingst, Jesper B. Birk, Anette Thorup, Jonas M. Kristensen, Kim A. Sjøberg, Bente Kiens, Erik A. Richter, Jørgen F.P. Wojtaszewski

Diabetes 2020;69(4):578–590

https://doi.org/10.2337/db19-1010

Published: 23 January 2020

View article titled, A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action

Journal Articles

PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis

Wenyi Wu, Guohong Zhou, Haote Han, Xionggao Huang, Heng Jiang, Shizuo Mukai, Andrius Kazlauskas, Jing Cui, Joanne Aiko Matsubara, Bart Vanhaesebroeck, Xiaobo Xia, Jiantao Wang, Hetian Lei

Diabetes 2020;69(4):736–748

https://doi.org/10.2337/db19-0713

Published: 08 January 2020

View article titled, PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis

Includes: Supplementary data

Journal Articles

Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate

Makoto Kurano, Kazuhisa Tsukamoto, Tomo Shimizu, Hidetoshi Kassai, Kazuki Nakao, Atsu Aiba, Masumi Hara, Yutaka Yatomi

Diabetes 2020;69(5):867–881

https://doi.org/10.2337/db19-0811

Published: 08 January 2020

View article titled, Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate

Includes: Supplementary data

Journal Articles

Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

Ivan Hernandez-Diaz, Jiaqi Pan, Carlo Alberto Ricciardi, Xiaoyan Bai, Jianting Ke, Kathryn E. White, Maria Flaquer, Georgia E. Fouli, Fulye Argunhan, Anthea E. Hayward, Fan Fan Hou, Giovanni E. Mann, Robert Q. Miao, David A. Long, Luigi Gnudi

Diabetes 2019;68(9):1841–1852

https://doi.org/10.2337/db19-0157

Published: 19 June 2019

View article titled, Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

Includes: Supplementary data

Meeting Abstracts

64-LB: Aerobic Exercise Decreases Hepatic Glucose Production via Asprosin Pathway in Diabetic Rats

JEONGRIM KO, TAE NYUN KIM, DAE YUN SEO, JIN HAN

Diabetes 2019;68(Supplement_1):64-LB

https://doi.org/10.2337/db19-64-LB

Published: 01 June 2019

View article titled, 64-LB: Aerobic Exercise Decreases Hepatic Glucose Production via Asprosin Pathway in Diabetic Rats

NARROW

10-OR: The Triple Roles of Tubular Mitochondria AKT in the Regulation of Renal Function, Insulin Resistance, and Body Composition during Development of Diabetic Nephropathy

Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

1303-P: Decreased Hepatic HMGB1 in Type 2 Diabetes Increases Mitochondrial Glucose Uptake by Regulating Insulin/AKT Signaling

1378-P: Chronic Sleep Deprivation Impaired Bone Formation in Growing Rats and Downregulated PI3K/AKT Signaling in Bone Tissues

Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination

29-LB: Exercise Effects on ?3-AMPK Activity, Akt Substrate of 160 kDa Phosphorylation, and Glucose Uptake in Muscle of Normal and Insulin-Resistant Female Rats

178-OR: Lipotoxicity Stimulates ß-Cell Extracellular Vesicle Secretion Which Induces ß-Cell Dysfunction and Perturbs ß-Cell Transcriptional Identity

121-OR: Activation of FoxO1 Induces Akt Phosphorylation and Mimics the Metabolic Functions of Insulin without Proliferative Effects on 3T3-L1 Adipocytes

WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2

1699-P: Mechanisms and Roles of Foxo1-Akt Negative Feedback Pathway in Adipocytes

1108-P: Resveratrol Inhibits Dapagliflozin-Induced Renal Gluconeogenesis through Modulating the PI3k/Akt/Foxo1 Pathway in HK-2 Cells

261-OR: CDK4-R24C Compensates for IRS2 Deficiency by Enhancing Beta-Cell Proliferation and Restoring Signaling through the AKT-Foxo1-PDX1 Pathway

1806-P: Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis

Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action

PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis

Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine-1-Phosphate

Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature

64-LB: Aerobic Exercise Decreases Hepatic Glucose Production via Asprosin Pathway in Diabetic Rats

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