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Journal Articles

GPCR Promiscuity Reshapes Islet Physiology

Frans Schuit, Jonathan E. Campbell

Diabetes 2023;72(9):1180–1183

https://doi.org/10.2337/dbi23-0014

Published: 21 August 2023

View article titled, GPCR Promiscuity Reshapes Islet Physiology

Meeting Abstracts

295-OR: Mechanisms of Antigen-Specific Immunotherapy following Tolerance Induction to a CD4 Hybrid Insulin Peptide Epitope and the Impact on CD8 T Cell Dysfunction

JAMES E. DILISIO, ROCKY L. BAKER, KATHRYN M. HASKINS

Diabetes 2023;72(Supplement_1):295-OR

https://doi.org/10.2337/db23-295-OR

Published: 20 June 2023

View article titled, 295-OR: Mechanisms of Antigen-Specific Immunotherapy following Tolerance Induction to a CD4 Hybrid Insulin Peptide Epitope and the Impact on CD8 T Cell Dysfunction

Meeting Abstracts

1727-P: Mitochondrial-Encoded Peptide MOTS-c Prevents Senescence-Induced Diabetes

BYUNGSOO KONG, SERIN HONG, YOUNG MIN CHO

Diabetes 2023;72(Supplement_1):1727-P

https://doi.org/10.2337/db23-1727-P

Published: 20 June 2023

View article titled, 1727-P: Mitochondrial-Encoded Peptide MOTS-c Prevents Senescence-Induced Diabetes

Meeting Abstracts

28-OR: Characterising a Novel Peptide That Inhibits and Reverses Type 1 Diabetes

THOMAS W. KING, SZUN S. TAY, FEYZA COLAKOGLU, MATT DEVALARAJA, ALAN REMALEY, MATÉ BIRO, BLAKE COCHRAN, KERRY ANNE RYE

Diabetes 2023;72(Supplement_1):28-OR

https://doi.org/10.2337/db23-28-OR

Published: 20 June 2023

View article titled, 28-OR: Characterising a Novel Peptide That Inhibits and Reverses Type 1 Diabetes

Meeting Abstracts

1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation

QING-RONG LIU, MIN ZHU, JOSEPHINE M. EGAN

Diabetes 2023;72(Supplement_1):1513-P

https://doi.org/10.2337/db23-1513-P

Published: 20 June 2023

View article titled, 1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation

Meeting Abstracts

1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets

KATIE C. COATE, XIN TONG, JIN-HUA LIU, REGINA JENKINS, RADHIKA ARAMANDLA, NANDITA DEY, SEUNG KIM, MARCELA BRISSOVA, ALVIN C. POWERS, ROLAND STEIN

Diabetes 2023;72(Supplement_1):1742-P

https://doi.org/10.2337/db23-1742-P

Published: 20 June 2023

View article titled, 1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets

Meeting Abstracts

1760-P: Mining Animal Venoms as a Source of Insulinotropic Peptides for Potential Diabetes Therapy

NATASHA HUI JIN NG, CHO YEOW KOH, CARMEN CHING, PONNAMPALAM GOPALAKRISHNAKONE, ADRIAN TEO

Diabetes 2023;72(Supplement_1):1760-P

https://doi.org/10.2337/db23-1760-P

Published: 20 June 2023

View article titled, 1760-P: Mining Animal Venoms as a Source of Insulinotropic Peptides for Potential Diabetes Therapy

Journal Articles

Comment on Liu et al. Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes. Diabetes 2022;71:722–732

Asimina Petsiou, George Vartholomatos, Agathocles Tsatsoulis, George K. Papadopoulos

Diabetes 2022;71(12):e20–e21

https://doi.org/10.2337/db22-0584

Published: 21 November 2022

View article titled, Comment on Liu et al. Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes. Diabetes 2022;71:722–732

Journal Articles

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4⁺ T Cells in Type 1 Diabetes

Perrin Guyer, David Arribas-Layton, Anthony Manganaro, Cate Speake, Sandra Lord, Decio L. Eizirik, Sally C. Kent, Roberto Mallone, Eddie A. James

Diabetes 2023;72(1):85–96

https://doi.org/10.2337/db22-0191

Published: 06 October 2022

View article titled, Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4<sup>+</sup> T Cells in Type 1 Diabetes

Journal Articles

Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes

Samantha A. Crawford, Timothy A. Wiles, Janet M. Wenzlau, Roger L. Powell, Gene Barbour, Mylinh Dang, Jason Groegler, Jessie M. Barra, KaLia S. Burnette, Anita C. Hohenstein, Rocky L. Baker, Hubert M. Tse, Kathryn Haskins, Thomas Delong

Diabetes 2022;71(12):2793–2803

https://doi.org/10.2337/db22-0303

Published: 30 August 2022

View article titled, Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes

Journal Articles

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini

Diabetes 2022;71(8):1735–1745

https://doi.org/10.2337/db21-1069

Published: 21 August 2022

View article titled, Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

Journal Articles

In This Issue of Diabetes

Max Bingham, PhD

Diabetes 2022;71(9):1829–1830

https://doi.org/10.2337/db22-ti09

Published: 11 August 2022

View article titled, In This Issue of <em>Diabetes</em>

Journal Articles

Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes

Zhenlong Chen, Jacob M. Haus, Lin Chen, Ying Jiang, Maria Sverdlov, Luisa A. DiPietro, Na Xiong, Stephanie C. Wu, Timothy J. Koh, Richard D. Minshall

Diabetes 2022;71(10):2166–2180

https://doi.org/10.2337/db21-1108

Published: 28 July 2022

View article titled, Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes

Journal Articles

PATAS, a First-in-Class Therapeutic Peptide Biologic, Improves Whole-Body Insulin Resistance and Associated Comorbidities In Vivo

Edwige Schreyer, Cathy Obringer, Nadia Messaddeq, Bruno Kieffer, Paul Zimmet, Alexander Fleming, Tarekegn Geberhiwot, Vincent Marion

Diabetes 2022;71(9):2034–2047

https://doi.org/10.2337/db22-0058

Published: 13 July 2022

View article titled, PATAS, a First-in-Class Therapeutic Peptide Biologic, Improves Whole-Body Insulin Resistance and Associated Comorbidities In Vivo

Meeting Abstracts

1134-P: Interlaboratory Standardization of C-Peptide Assays Using Certified Reference Material Corrected for Peptide Modifications

ZENGRU WU, KUANYSH KABYTAEV, JIANYING MU, SHAWN CONNOLLY, MICHAEL J. MCPHAUL, RANDIE R. LITTLE

Diabetes 2022;71(Supplement_1):1134-P

https://doi.org/10.2337/db22-1134-P

Published: 01 June 2022

View article titled, 1134-P: Interlaboratory Standardization of C-Peptide Assays Using Certified Reference Material Corrected for Peptide Modifications

Meeting Abstracts

184-OR: Antigen-Presenting Cells Can Generate Hybrid Peptides Identified in Type 1 Diabetes

SHAZAD A. KHOKHAR, MI LIU, JASON L. GAGLIA

Diabetes 2022;71(Supplement_1):184-OR

https://doi.org/10.2337/db22-184-OR

Published: 01 June 2022

View article titled, 184-OR: Antigen-Presenting Cells Can Generate Hybrid Peptides Identified in Type 1 Diabetes

Meeting Abstracts

1473-P: Combination Therapy with Dual-Function Peptide S1K and Insulin Reduces Blood Glucose Levels in Mouse Models of Type 1 Diabetes through Beta-Cell Regeneration and Immunosuppression

YOUNG-HOON LEE, HYEON-JEONG KIM, JI AE KIM, YUNSIL JANG, EUN-JOUNG MOON, HAE-JIN KIM

Diabetes 2022;71(Supplement_1):1473-P

https://doi.org/10.2337/db22-1473-P

Published: 01 June 2022

View article titled, 1473-P: Combination Therapy with Dual-Function Peptide S1K and Insulin Reduces Blood Glucose Levels in Mouse Models of Type 1 Diabetes through Beta-Cell Regeneration and Immunosuppression

Meeting Abstracts

111-LB: CHM-273S Peptide Decreases Blood Glucose Level, Improves Insulin Sensitivity, and Induces Insulin Signaling Pathways in the Liver of Rats with Diet-Induced Metabolic Disorder

VSEVOLOD PAVSHINTSEV, NIKITA MITKIN, IGOR DORONIN, EKATERINA EMELIANOVA, MAXIM LOVAT, GENNADY BABKIN, ANTON MALYSHEV

Diabetes 2022;71(Supplement_1):111-LB

https://doi.org/10.2337/db22-111-LB

Published: 01 June 2022

View article titled, 111-LB: CHM-273S Peptide Decreases Blood Glucose Level, Improves Insulin Sensitivity, and Induces Insulin Signaling Pathways in the Liver of Rats with Diet-Induced Metabolic Disorder

Meeting Abstracts

1297-P: Berberine Derivatives as Novel Antidiabetes Agents Targeting Intestinal AMPK and Antimicrobial Peptide-Controlled Gut Microbiome

ERYUN ZHANG

Diabetes 2022;71(Supplement_1):1297-P

https://doi.org/10.2337/db22-1297-P

Published: 01 June 2022

View article titled, 1297-P: Berberine Derivatives as Novel Antidiabetes Agents Targeting Intestinal AMPK and Antimicrobial Peptide-Controlled Gut Microbiome

Journal Articles

T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

Yi Jing, Yuelin Kong, John McGinty, Gabriele Blahnik-Fagan, Thomas Lee, Stephanie Orozco-Figueroa, Matthew L. Bettini, Eddie A. James, Maria Bettini

Diabetes 2022;71(5):1012–1022

https://doi.org/10.2337/db21-0993

Published: 18 February 2022

View article titled, T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

NARROW

GPCR Promiscuity Reshapes Islet Physiology

295-OR: Mechanisms of Antigen-Specific Immunotherapy following Tolerance Induction to a CD4 Hybrid Insulin Peptide Epitope and the Impact on CD8 T Cell Dysfunction

1727-P: Mitochondrial-Encoded Peptide MOTS-c Prevents Senescence-Induced Diabetes

28-OR: Characterising a Novel Peptide That Inhibits and Reverses Type 1 Diabetes

1513-P: IAPP25 in Beta Cells and DNSP11 in Alpha Cells Inhibit IAPP37 Fibrillation

1742-P: Loss of MAFB Compromises a-Cell Identity and Glucagon Secretion in Adult Human Islets

1760-P: Mining Animal Venoms as a Source of Insulinotropic Peptides for Potential Diabetes Therapy

Comment on Liu et al. Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes. Diabetes 2022;71:722–732

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4⁺ T Cells in Type 1 Diabetes

Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes

In This Issue of Diabetes

Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes

PATAS, a First-in-Class Therapeutic Peptide Biologic, Improves Whole-Body Insulin Resistance and Associated Comorbidities In Vivo

1134-P: Interlaboratory Standardization of C-Peptide Assays Using Certified Reference Material Corrected for Peptide Modifications

184-OR: Antigen-Presenting Cells Can Generate Hybrid Peptides Identified in Type 1 Diabetes

1473-P: Combination Therapy with Dual-Function Peptide S1K and Insulin Reduces Blood Glucose Levels in Mouse Models of Type 1 Diabetes through Beta-Cell Regeneration and Immunosuppression

111-LB: CHM-273S Peptide Decreases Blood Glucose Level, Improves Insulin Sensitivity, and Induces Insulin Signaling Pathways in the Liver of Rats with Diet-Induced Metabolic Disorder

1297-P: Berberine Derivatives as Novel Antidiabetes Agents Targeting Intestinal AMPK and Antimicrobial Peptide-Controlled Gut Microbiome

T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope

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