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Meeting Abstracts

294-OR: Hepatic Integrin ß1 Subunit Is Required for Liver Insulin Resistance but Not Fatty Liver in Diet-Induced Obese Mice

ELIJAH TREFTS, KAKALI GHOSHAL, ALLISON V. DO, AMANDA GUERIN, CHRISTOPHER GUAN, DEANNA BRACY, LOUISE LANTIER, ROY ZENT, AMBRA POZZI, DAVID H. WASSERMAN

Diabetes 2023;72(Supplement_1):294-OR

https://doi.org/10.2337/db23-294-OR

Published: 20 June 2023

View article titled, 294-OR: Hepatic Integrin ß1 Subunit Is Required for Liver Insulin Resistance but Not Fatty Liver in Diet-Induced Obese Mice

Meeting Abstracts

130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

BUKYUNG KIM, LAUREN A. TAUER, XIAODI HU, JASON K. KIM

Diabetes 2023;72(Supplement_1):130-OR

https://doi.org/10.2337/db23-130-OR

Published: 20 June 2023

View article titled, 130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

Meeting Abstracts

1688-P: Glucokinase Activator Triggers PERK-UPR Pathway in Diet-Induced Obese Mice via Inducing Hepatic Lipid Accumulation

NAN CAI, XUANRONG CHEN, JIA LIU, ZHEYAO WEN, SIYING WEN, WEN ZENG, SHUO LIN, YANMING CHEN, GUOJUN SHI, LONGYI ZENG

Diabetes 2023;72(Supplement_1):1688-P

https://doi.org/10.2337/db23-1688-P

Published: 20 June 2023

View article titled, 1688-P: Glucokinase Activator Triggers PERK-UPR Pathway in Diet-Induced Obese Mice via Inducing Hepatic Lipid Accumulation

Meeting Abstracts

210-OR: Long-Acting GIPR Agonism Enhances Body Weight Regulation of Multiple Weight-Reducing Agents in Diet-Induced Obese Mice

WILLIAM ROELL, LIBBEY O'FARRELL, AJIT REGMI, TAMER COSKUN

Diabetes 2023;72(Supplement_1):210-OR

https://doi.org/10.2337/db23-210-OR

Published: 20 June 2023

View article titled, 210-OR: Long-Acting GIPR Agonism Enhances Body Weight Regulation of Multiple Weight-Reducing Agents in Diet-Induced Obese Mice

Meeting Abstracts

1648-P: Triagonism Targeting GCGR/GLP-1/GIP-1 Receptors Improves Insulin Sensitivity in Obese Mice

TEAYOUN KIM, SHELLY NASON, JESSICA ANTIPENKO, KIRK M. HABEGGER

Diabetes 2023;72(Supplement_1):1648-P

https://doi.org/10.2337/db23-1648-P

Published: 20 June 2023

View article titled, 1648-P: Triagonism Targeting GCGR/GLP-1/GIP-1 Receptors Improves Insulin Sensitivity in Obese Mice

Journal Articles

The Double Face of IRF4 in Metabolic Reprogramming

Abdualrahman Mohammed Abdualkader, Gary D. Lopaschuk, Rami Al Batran

Diabetes 2022;71(11):2251–2252

https://doi.org/10.2337/dbi22-0026

Published: 13 October 2022

View article titled, The Double Face of IRF4 in Metabolic Reprogramming

Journal Articles

The Mechanism for Adipose Endotrophin Production

Yun Sok Lee

Diabetes 2022;71(8):1617–1619

https://doi.org/10.2337/dbi22-0008

Published: 21 August 2022

View article titled, The Mechanism for Adipose Endotrophin Production

Meeting Abstracts

272-OR: Weight Loss with Time-Restricted Feeding or Treatment with Obeticholic Acid/Semaglutide Combination Have a Different Impact on Nonalcoholic Steatohepatitis in Diet-Induced Obese Mice

FRANCOIS BRIAND, ESTELLE GRASSET, NATALIA BREYNER, THIERRY SULPICE

Diabetes 2022;71(Supplement_1):272-OR

https://doi.org/10.2337/db22-272-OR

Published: 01 June 2022

View article titled, 272-OR: Weight Loss with Time-Restricted Feeding or Treatment with Obeticholic Acid/Semaglutide Combination Have a Different Impact on Nonalcoholic Steatohepatitis in Diet-Induced Obese Mice

Meeting Abstracts

1462-P: Effect of Energy Restriction on the Intracellular Metabolism of Rodent Pancreatic ß-Cells In Vitro and Obese Mice

KOKI CHIBA, HIROSHI NOMOTO, RIMI IZUMIHARA, HIRAKU KAMEDA, KYUYONG CHO, HIDEAKI MIYOSHI, TATSUYA ATSUMI

Diabetes 2022;71(Supplement_1):1462-P

https://doi.org/10.2337/db22-1462-P

Published: 01 June 2022

View article titled, 1462-P: Effect of Energy Restriction on the Intracellular Metabolism of Rodent Pancreatic ß-Cells In Vitro and Obese Mice

Meeting Abstracts

1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice

PETR ZOUHAR

Diabetes 2022;71(Supplement_1):1379-P

https://doi.org/10.2337/db22-1379-P

Published: 01 June 2022

View article titled, 1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice

Meeting Abstracts

1455-P: The Loss of Pancreatic ß-Cell Complement 1q-Like-3 Secreted Protein Increases Insulin Secretion in Lean and Obese Mice

MOSTAFIZUR RAHMAN, MD, HAIFA ALSHARIF, SUSHANT BHATNAGAR

Diabetes 2022;71(Supplement_1):1455-P

https://doi.org/10.2337/db22-1455-P

Published: 01 June 2022

View article titled, 1455-P: The Loss of Pancreatic ß-Cell Complement 1q-Like-3 Secreted Protein Increases Insulin Secretion in Lean and Obese Mice

Meeting Abstracts

1405-P: Bacteroides thetaiotaomicron Fortifies the Gut Mucosa and Improves Host Metabolism in Dietary Obese Mice

JENNIFER LEE, KERRY WELLENSTEIN, BARBARA B. KAHN

Diabetes 2022;71(Supplement_1):1405-P

https://doi.org/10.2337/db22-1405-P

Published: 01 June 2022

View article titled, 1405-P: Bacteroides thetaiotaomicron Fortifies the Gut Mucosa and Improves Host Metabolism in Dietary Obese Mice

Meeting Abstracts

723-P: The Dual Glucagon and Glucagon-Like Peptide-1 Receptor (GCGR/GLP-1R) Agonist BI 4569Reduces Body Weight in Diet-Induced Obese Mice Based on Food Intake Reduction and an Increase in Energy Expenditure

TINA ZIMMERMANN, LEO THOMAS, TAMARA BAADER-PAGLER, PETER HAEBEL, HEIKE NEUBAUER, ERIC SIMON, WOLFGANG REINDL, BESNIK BAJRAMI, WOLFGANG RIST, INGO UPHUES, ROBERT AUGUSTIN

Diabetes 2022;71(Supplement_1):723-P

https://doi.org/10.2337/db22-723-P

Published: 01 June 2022

View article titled, 723-P: The Dual Glucagon and Glucagon-Like Peptide-1 Receptor (GCGR/GLP-1R) Agonist BI 4569Reduces Body Weight in Diet-Induced Obese Mice Based on Food Intake Reduction and an Increase in Energy Expenditure

Meeting Abstracts

1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

AMANDA A. GREENWELL, CHRISTINA T. SAED, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, KIM HO, KESHAV GOPAL, JORDAN S.F. CHAN, OKSANA KACZMAR, SCOTT A. DYER, FARAH EATON, GARY LOPASCHUK, RAMI A. BATRAN, JOHN R. USSHER

Diabetes 2022;71(Supplement_1):1397-P

https://doi.org/10.2337/db22-1397-P

Published: 01 June 2022

View article titled, 1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

Journal Articles

Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway

Qianxing Hu, Jinming Mu, Yuhong Liu, Yue Yang, Yue Liu, Yi Pan, Yanfeng Zhang, Ling Li, Dechen Liu, Jianqiu Chen, Fangfang Zhang, Liang Jin

Diabetes 2022;71(3):394–411

https://doi.org/10.2337/db21-0134

Published: 14 January 2022

View article titled, Obesity-Induced <em>miR-455</em> Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway

Meeting Abstracts

1205-P: Baricitinib Inhibition of Jak/STAT Pathway Changed Immune Composition in Adipose Tissue and Improved Metabolism in Diet-Induced Obese Mice

ZEQIN LIAN, XIAOYUAN PERRARD, CHRISTIE M. BALLANTYNE, HUAIZHU WU

Diabetes 2021;70(Supplement_1):1205-P

https://doi.org/10.2337/db21-1205-P

Published: 01 June 2021

View article titled, 1205-P: Baricitinib Inhibition of Jak/STAT Pathway Changed Immune Composition in Adipose Tissue and Improved Metabolism in Diet-Induced Obese Mice

Meeting Abstracts

332-OR: Pharmacological Inhibition of CREBZF Improves Insulin Resistance by Altering Activation of Macrophage in Adipose Tissue of Diet-Induced Obese Mice

YUXIAO LIU, ZHIMIN HU, ZHENGSHUAI LIU, WEITONG SU, ZENGPENG ZHENG, DONG DING, FENGGUANG MA, YAQIAN XUE, GENXIANG CAI, SHUANG WEI, ZIXUAN WANG, XIAOYANG SUN, YANG JIANG, XIAOZHEN DAI, YU LI, AOYUAN CUI

Diabetes 2021;70(Supplement_1):332-OR

https://doi.org/10.2337/db21-332-OR

Published: 01 June 2021

View article titled, 332-OR: Pharmacological Inhibition of CREBZF Improves Insulin Resistance by Altering Activation of Macrophage in Adipose Tissue of Diet-Induced Obese Mice

Meeting Abstracts

1250-P: Reg3g Mediates Sex-Specific Islet Dysfunction in Offspring of Obese Mice via Heparan Sulfate Glycan Polymerization

JAMES C. JARRELL, JOSE CASASNOVAS, LIM KUA

Diabetes 2021;70(Supplement_1):1250-P

https://doi.org/10.2337/db21-1250-P

Published: 01 June 2021

View article titled, 1250-P: Reg3g Mediates Sex-Specific Islet Dysfunction in Offspring of Obese Mice via Heparan Sulfate Glycan Polymerization

Journal Articles

Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver

Sunmi Seok, Hao Sun, Young-Chae Kim, Byron Kemper, Jongsook Kim Kemper

Diabetes 2021;70(3):733–744

https://doi.org/10.2337/db20-0856

Published: 16 December 2020

View article titled, Defective FXR-SHP Regulation in Obesity Aberrantly Increases <em>miR-802</em> Expression, Promoting Insulin Resistance and Fatty Liver

Journal Articles

STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity

Aaron R. Cox, Natasha Chernis, David A. Bader, Pradip K. Saha, Peter M. Masschelin, Jessica B. Felix, Robert Sharp, Zeqin Lian, Vasanta Putluri, Kimal Rajapakshe, Kang Ho Kim, Dennis T. Villareal, Reina Armamento-Villareal, Huaizhu Wu, Cristian Coarfa, Nagireddy Putluri, Sean M. Hartig

Diabetes 2020;69(12):2630–2641

https://doi.org/10.2337/db20-0384

Published: 29 September 2020

View article titled, STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity

NARROW

294-OR: Hepatic Integrin ß1 Subunit Is Required for Liver Insulin Resistance but Not Fatty Liver in Diet-Induced Obese Mice

130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

1688-P: Glucokinase Activator Triggers PERK-UPR Pathway in Diet-Induced Obese Mice via Inducing Hepatic Lipid Accumulation

210-OR: Long-Acting GIPR Agonism Enhances Body Weight Regulation of Multiple Weight-Reducing Agents in Diet-Induced Obese Mice

1648-P: Triagonism Targeting GCGR/GLP-1/GIP-1 Receptors Improves Insulin Sensitivity in Obese Mice

The Double Face of IRF4 in Metabolic Reprogramming

The Mechanism for Adipose Endotrophin Production

272-OR: Weight Loss with Time-Restricted Feeding or Treatment with Obeticholic Acid/Semaglutide Combination Have a Different Impact on Nonalcoholic Steatohepatitis in Diet-Induced Obese Mice

1462-P: Effect of Energy Restriction on the Intracellular Metabolism of Rodent Pancreatic ß-Cells In Vitro and Obese Mice

1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice

1455-P: The Loss of Pancreatic ß-Cell Complement 1q-Like-3 Secreted Protein Increases Insulin Secretion in Lean and Obese Mice

1405-P: Bacteroides thetaiotaomicron Fortifies the Gut Mucosa and Improves Host Metabolism in Dietary Obese Mice

723-P: The Dual Glucagon and Glucagon-Like Peptide-1 Receptor (GCGR/GLP-1R) Agonist BI 4569Reduces Body Weight in Diet-Induced Obese Mice Based on Food Intake Reduction and an Increase in Energy Expenditure

1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway

1205-P: Baricitinib Inhibition of Jak/STAT Pathway Changed Immune Composition in Adipose Tissue and Improved Metabolism in Diet-Induced Obese Mice

332-OR: Pharmacological Inhibition of CREBZF Improves Insulin Resistance by Altering Activation of Macrophage in Adipose Tissue of Diet-Induced Obese Mice

1250-P: Reg3g Mediates Sex-Specific Islet Dysfunction in Offspring of Obese Mice via Heparan Sulfate Glycan Polymerization

Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver

STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity

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