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Meeting Abstracts

29-OR: Diabetic Wound Keratinocytes Induce Macrophage JMJD3–Mediated Nlrp3 Expression

SONYA WOLF-FORTUNE, JADIE MOON, AMRITA JOSHI, PURBA MAZUMDER, EMILY BARRETT, KEVIN D. MANGUM, KATHERINE GALLAGHER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):29-OR
https://doi.org/10.2337/db23-29-OR
Published: 20 June 2023
View article titled, 29-OR: Diabetic Wound Keratinocytes Induce Macrophage JMJD3–Mediated Nlrp3 Expression
Meeting Abstracts

293-OR: Macrophage-Derived Interleukin-12 Regulates Obesity-Mediated Insulin Resistance in the Liver

RANDALL H. FRIEDLINE, MAHAA ALBUSHARIF, ALLISON M. KIM, LAUREN H. KIM, NATALIE M. BAEZ TORRES, LAUREN A. TAUER, XIAODI HU, JASON K. KIM
Journal: Diabetes
Diabetes 2023;72(Supplement_1):293-OR
https://doi.org/10.2337/db23-293-OR
Published: 20 June 2023
View article titled, 293-OR: Macrophage-Derived Interleukin-12 Regulates Obesity-Mediated Insulin Resistance in the Liver
Meeting Abstracts

32-OR: Reduction of Macrophage-iPLA2ß–Derived Proinflammatory Lipids Inhibit Type 1 Diabetes Development

ABDULAZIZ ALMUTAIRI, YING GAI, JERRY NADLER, CHARLES E. CHALFANT, SASANKA RAMANADHAM
Journal: Diabetes
Diabetes 2023;72(Supplement_1):32-OR
https://doi.org/10.2337/db23-32-OR
Published: 20 June 2023
View article titled, 32-OR: Reduction of Macrophage-iPLA2ß–Derived Proinflammatory Lipids Inhibit Type 1 Diabetes Development
Meeting Abstracts

252-LB: Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release from Macrophages and Impairs Glucose-Stimulated Insulin Secretion

MASAMICHI FUJITA, TAKASHI MIYAZAWA, KEIICHIRO UCHIDA, NAOHIRO UCHIDA, TOMOMI HATAYAMA, SHINTARO NAKAMURA, YUKINA TAKEICHI, YASUTAKA MIYACHI, YOSHIHIRO OGAWA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):252-LB
https://doi.org/10.2337/db23-252-LB
Published: 20 June 2023
View article titled, 252-LB: Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release from Macrophages and Impairs Glucose-Stimulated Insulin Secretion
Meeting Abstracts

393-P: Acute Hypoglycemia Alters Serum Immune Mediators Associated with Macrophage and T-Cell Activation in Type 2 Diabetes

ABU S. MOIN, THOZHUKAT SATHYAPALAN, STEPHEN ATKIN, ALEXANDRA E. BUTLER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):393-P
https://doi.org/10.2337/db23-393-P
Published: 20 June 2023
View article titled, 393-P: Acute Hypoglycemia Alters Serum Immune Mediators Associated with Macrophage and T-Cell Activation in Type 2 Diabetes
Meeting Abstracts

1689-P: Macrophage SUCLA2-Coupled Glutamine Metabolism Drives Obesity

HAOWEN JIANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1689-P
https://doi.org/10.2337/db23-1689-P
Published: 20 June 2023
View article titled, 1689-P: Macrophage SUCLA2-Coupled Glutamine Metabolism Drives Obesity
Meeting Abstracts

100-OR: A Novel Macrophage-Regulation Drug for Treating Diabetic Foot Ulcer—A Phase III MRCT Study and Taiwan Experience

SHYI-GEN CHEN, SHUN-TIEN CHU, CHI-MING PU, JUI-CHING CHEN, YI-HSIN WU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):100-OR
https://doi.org/10.2337/db23-100-OR
Published: 20 June 2023
View article titled, 100-OR: A Novel Macrophage-Regulation Drug for Treating Diabetic Foot Ulcer—A Phase III MRCT Study and Taiwan Experience
Meeting Abstracts

462-P: DPP-4 Deficiency Suppresses the Progression of Atherosclerosis via Inducing M2 Macrophage Polarization

YUQI ZHOU, TAKESHI MATSUMURA, YOSHITAKA YAGI, TOMOAKI YOSHINAGA, TAKAFUMI SENOKUCHI, NORIO ISHII, TATSUYA KONDO, EIICHI ARAKI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):462-P
https://doi.org/10.2337/db23-462-P
Published: 20 June 2023
View article titled, 462-P: DPP-4 Deficiency Suppresses the Progression of Atherosclerosis via Inducing M2 Macrophage Polarization
Meeting Abstracts

458-P: Proinflammatory Macrophage Phenotype Modulates Vascular Smooth Muscle Cell Differentiation via the Histone Demethylase JMJD3

KEVIN D. MANGUM, AMRITA JOSHI, PURBA MAZUMDER, SONYA WOLF-FORTUNE, EMILY BARRETT, BETHANY MOORE, FRANK M. DAVIS, KATHERINE GALLAGHER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):458-P
https://doi.org/10.2337/db23-458-P
Published: 20 June 2023
View article titled, 458-P: Proinflammatory Macrophage Phenotype Modulates Vascular Smooth Muscle Cell Differentiation via the Histone Demethylase JMJD3
Meeting Abstracts

322-OR: Proinflammatory Macrophage Infiltration in Sural Nerve Is Associated with Reduction of Myelinated Nerve Fiber Density but Not IENFD in Human Diabetic Subjects

HIROKI MIZUKAMI, SHO OSONOI, YUKI TAKEUCHI, TAKANORI SASAKI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):322-OR
https://doi.org/10.2337/db23-322-OR
Published: 20 June 2023
View article titled, 322-OR: Proinflammatory Macrophage Infiltration in Sural Nerve Is Associated with Reduction of Myelinated Nerve Fiber Density but Not IENFD in Human Diabetic Subjects
Meeting Abstracts

344-OR: Post-translational Modification of SHDA Regulating Macrophage Polarization and Inflammation in Obesity

RUI WU, HAOWEN JIANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):344-OR
https://doi.org/10.2337/db23-344-OR
Published: 20 June 2023
View article titled, 344-OR: Post-translational Modification of SHDA Regulating Macrophage Polarization and Inflammation in Obesity
Meeting Abstracts

1640-P: Meroterpenoid-Rich Ethanolic Extract of Sargassum serratifolium (MES) Alters Macrophage Transcriptome and Secretion Profile toward Improving Muscle Atrophy and Glucose Intolerance

HEEYEON RYU, BONGGI LEE
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1640-P
https://doi.org/10.2337/db23-1640-P
Published: 20 June 2023
View article titled, 1640-P: Meroterpenoid-Rich Ethanolic Extract of Sargassum serratifolium (MES) Alters Macrophage Transcriptome and Secretion Profile toward Improving Muscle Atrophy and Glucose Intolerance
Journal Articles

Loss of Hematopoietic Cell–Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice

Mattia Albiero, Stefano Ciciliot, Anna Rodella, Ludovica Migliozzi, Francesco Ivan Amendolagine, Carlotta Boscaro, Gaia Zuccolotto, Antonio Rosato, Gian Paolo Fadini
Journal: Diabetes
Diabetes 2023;72(4):483–495
https://doi.org/10.2337/db22-0054
Published: 19 January 2023
View article titled, Loss of Hematopoietic Cell–Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice
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Journal Articles

miR-210-3p Promotes Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Targeting SOCS1-Mediated NF-κB Pathway

Debarun Patra, Soumyajit Roy, Leena Arora, Shaheen Wasil Kabeer, Satpal Singh, Upalabdha Dey, Dipanjan Banerjee, Archana Sinha, Suman Dasgupta, Kulbhushan Tikoo, Aditya Kumar, Durba Pal
Journal: Diabetes
Diabetes 2023;72(3):375–388
https://doi.org/10.2337/db22-0284
Published: 05 December 2022
View article titled, <em>miR-210-3p</em> Promotes Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Targeting SOCS1-Mediated NF-κB Pathway
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Journal Articles

Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling

Danny Luan, Benyamin Dadpey, Jessica Zaid, Pania E. Bridge-Comer, Julia H. DeLuca, Wenmin Xia, Joshua Castle, Shannon M. Reilly
Journal: Diabetes
Diabetes 2023;72(3):367–374
https://doi.org/10.2337/db22-0444
Published: 30 November 2022
View article titled, Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
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Journal Articles

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Journal: Diabetes
Diabetes 2023;72(2):261–274
https://doi.org/10.2337/db22-0521
Published: 08 November 2022
View article titled, An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
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Journal Articles

Identifying Hyperreflective Foci in Diabetic Retinopathy via VEGF-Induced Local Self-Renewal of CX3CR1+ Vitreous Resident Macrophages

Muneo Yamaguchi, Shintaro Nakao, Iori Wada, Tetsuya Matoba, Mitsuru Arima, Yoshihiro Kaizu, Mariko Shirane, Keijiro Ishikawa, Takahito Nakama, Yusuke Murakami, Masaharu Mizuochi, Wataru Shiraishi, Ryo Yamasaki, Toshio Hisatomi, Tatsuro Ishibashi, Masabumi Shibuya, Alan W. Stitt, Koh-Hei Sonoda
Journal: Diabetes
Diabetes 2022;71(12):2685–2701
https://doi.org/10.2337/db21-0247
Published: 07 October 2022
View article titled, Identifying Hyperreflective Foci in Diabetic Retinopathy via VEGF-Induced Local Self-Renewal of CX3CR1<sup>+</sup> Vitreous Resident Macrophages
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Journal Articles

TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling

Hwan Hee Lee, Gyu Won Jeong, Byeong Jin Ye, Eun Jin Yoo, Keoung Sun Son, Dong Ki Kim, Hye-Kyung Park, Byoung Heon Kang, Whaseon Lee-Kwon, Hyug Moo Kwon, Soo Youn Choi
Journal: Diabetes
Diabetes 2022;71(12):2557–2571
https://doi.org/10.2337/db21-1099
Published: 28 September 2022
View article titled, TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling
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Journal Articles

Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies

Kate M. Root, Brian Akhaphong, Melissa A. Cedars, Alexa M. Molin, Margaretta E. Huchthausen, Connor F. Laule, Ronald R. Regal, Emilyn U. Alejandro, Jean F. Regal
Journal: Diabetes
Diabetes 2022;71(12):2597–2611
https://doi.org/10.2337/db22-0404
Published: 20 September 2022
View article titled, Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies
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Journal Articles

Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages

Wenyu Gou, Wei Hua, Lindsay Swaby, Wanxing Cui, Erica Green, Katherine A. Morgan, Charlie Strange, Hongjun Wang
Journal: Diabetes
Diabetes 2022;71(12):2642–2655
https://doi.org/10.2337/db22-0117
Published: 06 September 2022
View article titled, Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages
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