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Meeting Abstracts

1617-P: Small Intestinal Protein Sensing Mechanism in Feeding and Glucose Regulation

DANIEL BARROS, ROSA J.W. LI, YUMI LIM, SONG-YANG ZHANG, RACHEL KUAH, ANNA GAO, TONY K. LAM

Diabetes 2023;72(Supplement_1):1617-P

https://doi.org/10.2337/db23-1617-P

Published: 20 June 2023

View article titled, 1617-P: Small Intestinal Protein Sensing Mechanism in Feeding and Glucose Regulation

Meeting Abstracts

1358-P: Small Intestinal Casein Sensing Regulates Food Intake and Glucose Tolerance in Rats

ROSA J.W. LI, DANIEL BARROS, YUMI LIM, SONGYANG ZHANG, ANNA GAO, TONY K. LAM

Diabetes 2022;71(Supplement_1):1358-P

https://doi.org/10.2337/db22-1358-P

Published: 01 June 2022

View article titled, 1358-P: Small Intestinal Casein Sensing Regulates Food Intake and Glucose Tolerance in Rats

Meeting Abstracts

1670-P: Enalapril Maleate, Angiotensin-Converting Enzyme Inhibitor, Suppresses the Expression of the MHC Molecules in Mucosal Cells of the Small Intestine Leading to the Delayed Onset of Autoimmune Type 1 Diabetes Mellitus in NOD Mice

MASAKAZU HATTORI, AIKO UEDA, RYUICHI KATOH, MASATAKA HIRAI, AKIHIRO NODA, KAZUYA MAYANAGI, YOSHITO FURUICHI, KIMIE HATTORI, TORBEN LUND, KENJI KOBAYASHI, YASUYUKI NAKAMURA

Diabetes 2020;69(Supplement_1):1670-P

https://doi.org/10.2337/db20-1670-P

Published: 01 June 2020

View article titled, 1670-P: Enalapril Maleate, Angiotensin-Converting Enzyme Inhibitor, Suppresses the Expression of the MHC Molecules in Mucosal Cells of the Small Intestine Leading to the Delayed Onset of Autoimmune Type 1 Diabetes Mellitus in NOD Mice

Meeting Abstracts

71-OR: Oligofructose Improves Small Intestinal Nutrient-Sensing Mechanisms via the Small Intestinal Microbiota

SAVANNA N. WENINGER, EVE BEAUCHEMIN, ADELINA I.L. LANE, RACHEL MEYER, FRANK DUCA

Diabetes 2020;69(Supplement_1):71-OR

https://doi.org/10.2337/db20-71-OR

Published: 01 June 2020

View article titled, 71-OR: Oligofructose Improves Small Intestinal Nutrient-Sensing Mechanisms via the Small Intestinal Microbiota

Meeting Abstracts

1905-P: Downregulation of HMGCS2 Expression in Small Intestinal Mucosa Biopsies after Roux-en-Y Gastric Bypass Surgery: A Possible Contributor to GLP-1 Hypersecretion?

CHRISTIAN LEGART, TINA JORSAL, CHRISTOFFER A. HAGEMANN, DORTE WORM, CLAUS B. JUHL, ALIN R. ANDRIES, CHEN ZHANG, NIELS VRANG, KRISTOFFER RIGBOLT, JACOB JELSING, TINA VILSBØLL, FILIP K. KNOP

Diabetes 2020;69(Supplement_1):1905-P

https://doi.org/10.2337/db20-1905-P

Published: 01 June 2020

View article titled, 1905-P: Downregulation of HMGCS2 Expression in Small Intestinal Mucosa Biopsies after Roux-en-Y Gastric Bypass Surgery: A Possible Contributor to GLP-1 Hypersecretion?

Meeting Abstracts

125-LB: An Ingestible Capsule to Deliver Parenteral Pharmaceuticals into the Jejunal Wall

Diabetes 2019;68(Supplement_1):125-LB

https://doi.org/10.2337/db19-125-LB

Published: 01 June 2019

View article titled, 125-LB: An Ingestible Capsule to Deliver Parenteral Pharmaceuticals into the Jejunal Wall

Meeting Abstracts

Lactobacillus Gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid Sensing Pathway That Regulates Whole-Body Glucose Homeostasis

PAIGE V. BAUER, FRANK DUCA, T.M. ZAVED WAISE, HELEN J. DRANSE, BRITTANY A. RASMUSSEN-SMALL, AKSHITA PURI, MOZHGAN RASTI, TONY K.T. LAM

Diabetes 2018;67(Supplement_1):1948-P

https://doi.org/10.2337/db18-1948-P

Published: 01 July 2018

View article titled, Lactobacillus Gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid Sensing Pathway That Regulates Whole-Body Glucose Homeostasis

Meeting Abstracts

Generation of Insulin Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD

LEE SO HYUN, JIWON KIM, KUN-HO YOON

Diabetes 2018;67(Supplement_1):2165-P

https://doi.org/10.2337/db18-2165-P

Published: 01 July 2018

View article titled, Generation of Insulin Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD

Journal Articles

The Gastrointestinal Tract as an Integrator of Mechanical and Hormonal Response to Nutrient Ingestion

Adrian Vella, Michael Camilleri

Diabetes 2017;66(11):2729–2737

https://doi.org/10.2337/dbi17-0021

Published: 13 October 2017

View article titled, The Gastrointestinal Tract as an Integrator of Mechanical and Hormonal Response to Nutrient Ingestion

Journal Articles

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine

Emily W. Sun, Dayan de Fontgalland, Philippa Rabbitt, Paul Hollington, Luigi Sposato, Steven L. Due, David A. Wattchow, Christopher K. Rayner, Adam M. Deane, Richard L. Young, Damien J. Keating

Diabetes 2017;66(8):2144–2149

https://doi.org/10.2337/db17-0058

Published: 06 April 2017

View article titled, Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine

Includes: Supplementary data

Journal Articles

Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes

Henri Honka, Jukka Koffert, Saila Kauhanen, Jarmo Teuho, Saija Hurme, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop, Pirjo Nuutila

Diabetes 2017;66(4):880–885

https://doi.org/10.2337/db16-0762

Published: 17 January 2017

View article titled, Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes

Includes: Supplementary data

Journal Articles

Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy

Cheol Ryong Ku, Narae Lee, Jae Won Hong, In Gyu Kwon, Woo Jin Hyung, Sung Hoon Noh, Eun Jig Lee, Mijin Yun, Arthur Cho

Diabetes 2017;66(2):385–391

https://doi.org/10.2337/db16-1000

Published: 30 November 2016

View article titled, Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy

Includes: Supplementary data

Journal Articles

[¹¹C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency

Jonas B. Jensen, Elias I. Sundelin, Steen Jakobsen, Lars C. Gormsen, Ole L. Munk, Jørgen Frøkiær, Niels Jessen

Diabetes 2016;65(6):1724–1730

https://doi.org/10.2337/db16-0032

Published: 18 March 2016

View article titled, [<sup>11</sup>C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency

Includes: Supplementary data

Journal Articles

The Glucagon-Like Peptide 1 Receptor Agonist Exenatide Inhibits Small Intestinal Motility, Flow, Transit, and Absorption of Glucose in Healthy Subjects and Patients With Type 2 Diabetes: A Randomized Controlled Trial

Sony S. Thazhath, Chinmay S. Marathe, Tongzhi Wu, Jessica Chang, Joan Khoo, Paul Kuo, Helen L. Checklin, Michelle J. Bound, Rachael S. Rigda, Benjamin Crouch, Karen L. Jones, Michael Horowitz, Christopher K. Rayner

Diabetes 2016;65(1):269–275

https://doi.org/10.2337/db15-0893

Published: 15 October 2015

View article titled, The Glucagon-Like Peptide 1 Receptor Agonist Exenatide Inhibits Small Intestinal Motility, Flow, Transit, and Absorption of Glucose in Healthy Subjects and Patients With Type 2 Diabetes: A Randomized Controlled Trial

Includes: Supplementary data

Journal Articles

An Absorbing Sense of Sweetness

Fiona M. Gribble

Diabetes 2015;64(2):338–340

https://doi.org/10.2337/db14-1477

Published: 13 January 2015

View article titled, An Absorbing Sense of Sweetness

Journal Articles

Small Intestinal Glucose Exposure Determines the Magnitude of the Incretin Effect in Health and Type 2 Diabetes

Chinmay S. Marathe, Christopher K. Rayner, Michelle Bound, Helen Checklin, Scott Standfield, Judith Wishart, Kylie Lange, Karen L. Jones, Michael Horowitz

Diabetes 2014;63(8):2668–2675

https://doi.org/10.2337/db13-1757

Published: 17 July 2014

View article titled, Small Intestinal Glucose Exposure Determines the Magnitude of the Incretin Effect in Health and Type 2 Diabetes

Journal Articles

Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion

Serenella Salinari, Carel W. le Roux, Alessandro Bertuzzi, Francesco Rubino, Geltrude Mingrone

Diabetes 2014;63(3):1069–1078

https://doi.org/10.2337/db13-0856

Published: 13 February 2014

View article titled, Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion

Journal Articles

Generation of L Cells in Mouse and Human Small Intestine Organoids

Natalia Petersen, Frank Reimann, Sina Bartfeld, Henner F. Farin, Femke C. Ringnalda, Robert G.J. Vries, Stieneke van den Brink, Hans Clevers, Fiona M. Gribble, Eelco J.P. de Koning

Diabetes 2014;63(2):410–420

https://doi.org/10.2337/db13-0991

Published: 16 January 2014

View article titled, Generation of L Cells in Mouse and Human Small Intestine Organoids

Includes: Supplementary data

Journal Articles

Overnutrition Stimulates Intestinal Epithelium Proliferation Through β-Catenin Signaling in Obese Mice

Jiaming Mao, Xiaomin Hu, Yao Xiao, Chao Yang, Yi Ding, Ning Hou, Jue Wang, Heping Cheng, Xiuqin Zhang

Diabetes 2013;62(11):3736–3746

https://doi.org/10.2337/db13-0035

Published: 18 October 2013

View article titled, Overnutrition Stimulates Intestinal Epithelium Proliferation Through β-Catenin Signaling in Obese Mice

Journal Articles

Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes

Changyun Hu, Heyuan Ding, Xiaojun Zhang, F. Susan Wong, Li Wen

Diabetes 2013;62(8):2849–2858

https://doi.org/10.2337/db12-1175

Published: 17 July 2013

View article titled, Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes

Includes: Supplementary data

NARROW

1617-P: Small Intestinal Protein Sensing Mechanism in Feeding and Glucose Regulation

1358-P: Small Intestinal Casein Sensing Regulates Food Intake and Glucose Tolerance in Rats

1670-P: Enalapril Maleate, Angiotensin-Converting Enzyme Inhibitor, Suppresses the Expression of the MHC Molecules in Mucosal Cells of the Small Intestine Leading to the Delayed Onset of Autoimmune Type 1 Diabetes Mellitus in NOD Mice

71-OR: Oligofructose Improves Small Intestinal Nutrient-Sensing Mechanisms via the Small Intestinal Microbiota

1905-P: Downregulation of HMGCS2 Expression in Small Intestinal Mucosa Biopsies after Roux-en-Y Gastric Bypass Surgery: A Possible Contributor to GLP-1 Hypersecretion?

125-LB: An Ingestible Capsule to Deliver Parenteral Pharmaceuticals into the Jejunal Wall

Lactobacillus Gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid Sensing Pathway That Regulates Whole-Body Glucose Homeostasis

Generation of Insulin Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD

The Gastrointestinal Tract as an Integrator of Mechanical and Hormonal Response to Nutrient Ingestion

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine

Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes

Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy

[¹¹C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency

The Glucagon-Like Peptide 1 Receptor Agonist Exenatide Inhibits Small Intestinal Motility, Flow, Transit, and Absorption of Glucose in Healthy Subjects and Patients With Type 2 Diabetes: A Randomized Controlled Trial

An Absorbing Sense of Sweetness

Small Intestinal Glucose Exposure Determines the Magnitude of the Incretin Effect in Health and Type 2 Diabetes

Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion

Generation of L Cells in Mouse and Human Small Intestine Organoids

Overnutrition Stimulates Intestinal Epithelium Proliferation Through β-Catenin Signaling in Obese Mice

Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes

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