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Journal Articles

Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia

Harry B. Cutler, Søren Madsen, Stewart W.C. Masson, Kristen C. Cooke, Meg Potter, James G. Burchfield, Jacqueline Stöckli, Marin E. Nelson, Gregory J. Cooney, David E. James
Journal: Diabetes
Diabetes db230035
https://doi.org/10.2337/db23-0035
Published: 12 September 2023
View article titled, Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia
Open the PDF for Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia in another window
Journal Articles

Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes

Martin Schön, Oana P. Zaharia, Klaus Strassburger, Yuliya Kupriyanova, Kálmán Bódis, Geronimo Heilmann, Alexander Strom, Gidon J. Bönhof, Filippo Michelotti, Iryna Yurchenko, Clara Möser, Maximilian Huttasch, Maria Bombrich, Malte Kelm, Volker Burkart, Vera B. Schrauwen-Hinderling, Robert Wagner, Michael Roden, GDS Group, M. Roden, H. Al-Hasani, B. Belgardt, G.J. Bönhof, V. Burkart, A.E. Buyken, G. Geerling, C. Herder, A. Icks, K. Jandeleit-Dahm, J. Kotzka, O. Kuß, E. Lammert, W. Rathmann, V. Schrauwen-Hinderling, J. Szendroedi, S. Trenkamp, R. Wagner
Journal: Diabetes
Diabetes 2023;72(10):1483–1492
https://doi.org/10.2337/db23-0353
Published: 21 July 2023
View article titled, Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes
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Meeting Abstracts

177-OR: Worsening Insulin Resistance Is Key Pathological Contributor to Dysglycemia in Lean Koreans—A Longitudinal Validation Study in the Korean Genome and Epidemiology Study (KoGES)

DOOHWA KIM, JINMI KIM, MYUNGSOO IM, SOREE RYANG, WOOK YI, MINSOO KIM, YEONG JIN KIM, IN JOO KIM, YOUNG JIN KIM, HYUK KANG, ARTHUR SHERMAN, STEPHANIE T. CHUNG, SANG SOO KIM, JOON HA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):177-OR
https://doi.org/10.2337/db23-177-OR
Published: 20 June 2023
View article titled, 177-OR: Worsening Insulin Resistance Is Key Pathological Contributor to Dysglycemia in Lean Koreans—A Longitudinal Validation Study in the Korean Genome and Epidemiology Study (KoGES)
Meeting Abstracts

1148-P: Glycoprotein Acetyls (GlycA) Associate with Intraglomerular Hemodynamic Dysfunction, Albuminuria, Central Adiposity, and Insulin Resistance (IR) in Youth with Type 1 Diabetes (T1D)

TRENTON REINICKE, ALYSSA CALDWELL-MCGEE, CARISSA BIRZNIEKS, DIEGO CARRASCO, M. LOREDANA MARCOVECCHIO, KRISTEN J. NADEAU, KALIE L. TOMMERDAHL, MEGHAN E. PAULEY, JANET K. SNELL-BERGEON, SUSAN GROSS, DAVID CHERNEY, TIMOTHY B. VIGERS, LAURA PYLE, LYNETTE DRISCOLL, FARID H. MAHMUD, ALLISON DART, MEDA E. PAVKOV, ROBERT G. NELSON, PETTER BJORNSTAD
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1148-P
https://doi.org/10.2337/db23-1148-P
Published: 20 June 2023
View article titled, 1148-P: Glycoprotein Acetyls (GlycA) Associate with Intraglomerular Hemodynamic Dysfunction, Albuminuria, Central Adiposity, and Insulin Resistance (IR) in Youth with Type 1 Diabetes (T1D)
Meeting Abstracts

829-P: Outcomes with Finerenone in People with CKD and T2D by Baseline Insulin Resistance—A FIDELITY Subgroup Analysis

THOMAS EBERT, STEFAN ANKER, LUIS M. RUILOPE, PAOLA FIORETTO, VIVIAN FONSECA, GUILLERMO UMPIERREZ, ANDREAS L. BIRKENFELD, ROBERT LAWATSCHECK, CHARLIE SCOTT, KATJA ROHWEDDER, PETER ROSSING
Journal: Diabetes
Diabetes 2023;72(Supplement_1):829-P
https://doi.org/10.2337/db23-829-P
Published: 20 June 2023
View article titled, 829-P: Outcomes with Finerenone in People with CKD and T2D by Baseline Insulin Resistance—A FIDELITY Subgroup Analysis
Meeting Abstracts

1603-P: Differential Effects of Cocoa Butter, Sunflower, Soybean, and Fish Oil Based Sucrose-Free HFDs on Hepatic Steatosis, Lipogenesis, Inflammation, and Insulin Resistance in Mice

RASHEED AHMAD, TEXY K. JACOB, SHIHAB P. KOCHUMON, REEBY S. THOMAS, STEVE SHENOUDA, NADEEM AKHTER, AJIT WILSON, FATEMAH BAHMAN, AMAL HASAN, FATEMA ALRASHED, HOSSEIN AREFANIAN, ASHRAF AL MADHOUN, FAHD ALMULLA, SARDAR T.A.K. SINDHU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1603-P
https://doi.org/10.2337/db23-1603-P
Published: 20 June 2023
View article titled, 1603-P: Differential Effects of Cocoa Butter, Sunflower, Soybean, and Fish Oil Based Sucrose-Free HFDs on Hepatic Steatosis, Lipogenesis, Inflammation, and Insulin Resistance in Mice
Meeting Abstracts

294-OR: Hepatic Integrin ß1 Subunit Is Required for Liver Insulin Resistance but Not Fatty Liver in Diet-Induced Obese Mice

ELIJAH TREFTS, KAKALI GHOSHAL, ALLISON V. DO, AMANDA GUERIN, CHRISTOPHER GUAN, DEANNA BRACY, LOUISE LANTIER, ROY ZENT, AMBRA POZZI, DAVID H. WASSERMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):294-OR
https://doi.org/10.2337/db23-294-OR
Published: 20 June 2023
View article titled, 294-OR: Hepatic Integrin ß1 Subunit Is Required for Liver Insulin Resistance but Not Fatty Liver in Diet-Induced Obese Mice
Meeting Abstracts

293-OR: Macrophage-Derived Interleukin-12 Regulates Obesity-Mediated Insulin Resistance in the Liver

RANDALL H. FRIEDLINE, MAHAA ALBUSHARIF, ALLISON M. KIM, LAUREN H. KIM, NATALIE M. BAEZ TORRES, LAUREN A. TAUER, XIAODI HU, JASON K. KIM
Journal: Diabetes
Diabetes 2023;72(Supplement_1):293-OR
https://doi.org/10.2337/db23-293-OR
Published: 20 June 2023
View article titled, 293-OR: Macrophage-Derived Interleukin-12 Regulates Obesity-Mediated Insulin Resistance in the Liver
Meeting Abstracts

292-OR: High-Fat Diets Containing Sucrose and Fructose, but Not Glucose, Induce Obesity and Hepatic Insulin Resistance via Accumulation of Diacylglycerols

SE-HYUNG PARK, TAGHREED I. FADHUL, C. RONALD KAHN, SAMIR SOFTIC
Journal: Diabetes
Diabetes 2023;72(Supplement_1):292-OR
https://doi.org/10.2337/db23-292-OR
Published: 20 June 2023
View article titled, 292-OR: High-Fat Diets Containing Sucrose and Fructose, but Not Glucose, Induce Obesity and Hepatic Insulin Resistance via Accumulation of Diacylglycerols
Meeting Abstracts

1521-P: Healthy, Nonobese South Asian Men Have Both Greater Peripheral and Hepatic Insulin Resistance than Chinese Men

AMANDA Y.L. LIM, HONG CHANG TAN, CHIN MENG KHOO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1521-P
https://doi.org/10.2337/db23-1521-P
Published: 20 June 2023
View article titled, 1521-P: Healthy, Nonobese South Asian Men Have Both Greater Peripheral and Hepatic Insulin Resistance than Chinese Men
Meeting Abstracts

1099-P: Plasma Amino Acid Profiles in Childhood Predict 10-Year Risk of Insulin Resistance in Adulthood—The BCAMS Study

SHAN GAO, MING LI, BCAMS GROUP
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1099-P
https://doi.org/10.2337/db23-1099-P
Published: 20 June 2023
View article titled, 1099-P: Plasma Amino Acid Profiles in Childhood Predict 10-Year Risk of Insulin Resistance in Adulthood—The BCAMS Study
Meeting Abstracts

279-LB: The Role of Body Composition Phenotypes on Insulin Resistance in Nondiabetic Asians—The Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011

AH REUM KHANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):279-LB
https://doi.org/10.2337/db23-279-LB
Published: 20 June 2023
View article titled, 279-LB: The Role of Body Composition Phenotypes on Insulin Resistance in Nondiabetic Asians—The Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011
Meeting Abstracts

46-OR: Amelioration of Insulin Resistance after Delivery Lowers the Risk of Postpartum Type 2 Diabetes in Women with Gestational Diabetes Mellitus

HEEJUN SON, JOON HO MOON, NAM H. CHO, HAK CHUL JANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):46-OR
https://doi.org/10.2337/db23-46-OR
Published: 20 June 2023
View article titled, 46-OR: Amelioration of Insulin Resistance after Delivery Lowers the Risk of Postpartum Type 2 Diabetes in Women with Gestational Diabetes Mellitus
Meeting Abstracts

581-P: The Effects of Resistance Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes

MITCHELL SAMMUT, DAVID MCBEY, C.W. JAMES MELLING
Journal: Diabetes
Diabetes 2023;72(Supplement_1):581-P
https://doi.org/10.2337/db23-581-P
Published: 20 June 2023
View article titled, 581-P: The Effects of Resistance Training on Insulin Resistance Development in Female Rodents with Type 1 Diabetes
Meeting Abstracts

1561-P: Dietary Proteins Impact Glucose Tolerance and Hepatic Insulin Resistance in Mice through Modulation of the Urea Cycle

FRÉDÉRIC BÉGIN, ALEXANDRE CARON, ANDRE MARETTE
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1561-P
https://doi.org/10.2337/db23-1561-P
Published: 20 June 2023
View article titled, 1561-P: Dietary Proteins Impact Glucose Tolerance and Hepatic Insulin Resistance in Mice through Modulation of the Urea Cycle
Meeting Abstracts

289-OR: Defining Pathway-Selective Insulin Resistance in Type 2 Diabetes Using iPS Cell-Derived Hepatocytes

ARIJEET GATTU, ANNA KROOK, JULEEN R. ZIERATH, MATTHIAS MANN, C. RONALD KAHN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):289-OR
https://doi.org/10.2337/db23-289-OR
Published: 20 June 2023
View article titled, 289-OR: Defining Pathway-Selective Insulin Resistance in Type 2 Diabetes Using iPS Cell-Derived Hepatocytes
Meeting Abstracts

1510-P: Lipid-Induced Renal Cortical Insulin Resistance Perturbs Gluconeogenic and Oxidative Metabolism via an sn-1,2-diacylglycerol-PKCe-Insulin Receptor Kinase Axis In Vivo

BRANDON T. HUBBARD, RAFAEL C. GASPAR, DONGYAN ZHANG, MARIO KAHN, ALI NASIRI, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1510-P
https://doi.org/10.2337/db23-1510-P
Published: 20 June 2023
View article titled, 1510-P: Lipid-Induced Renal Cortical Insulin Resistance Perturbs Gluconeogenic and Oxidative Metabolism via an sn-1,2-diacylglycerol-PKCe-Insulin Receptor Kinase Axis In Vivo
Meeting Abstracts

1489-P: iPLA2gamma as a Mediator of Lipid-Induced Metabolic Inflammation and Insulin Resistance

MYUNG-SHIK LEE, HYEREEN KANG
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1489-P
https://doi.org/10.2337/db23-1489-P
Published: 20 June 2023
View article titled, 1489-P: iPLA2gamma as a Mediator of Lipid-Induced Metabolic Inflammation and Insulin Resistance
Meeting Abstracts

1311-P: Insulin Resistance in Non-obese Young Adults with Type 1 Diabetes

CATHERINE J. CHARTIER-LOGAN, IRENE E. SCHAUER, MELANIE CREE-GREEN, LAURA PYLE, BRYAN C. BERGMAN, JANET K. SNELL-BERGEON
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1311-P
https://doi.org/10.2337/db23-1311-P
Published: 20 June 2023
View article titled, 1311-P: Insulin Resistance in Non-obese Young Adults with Type 1 Diabetes
Meeting Abstracts

130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

BUKYUNG KIM, LAUREN A. TAUER, XIAODI HU, JASON K. KIM
Journal: Diabetes
Diabetes 2023;72(Supplement_1):130-OR
https://doi.org/10.2337/db23-130-OR
Published: 20 June 2023
View article titled, 130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice