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Journal Articles

Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia

Harry B. Cutler, Søren Madsen, Stewart W.C. Masson, Kristen C. Cooke, Meg Potter, James G. Burchfield, Jacqueline Stöckli, Marin E. Nelson, Gregory J. Cooney, David E. James
Journal: Diabetes
Diabetes db230035
https://doi.org/10.2337/db23-0035
Published: 12 September 2023
View article titled, Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia
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Journal Articles

GPCR Promiscuity Reshapes Islet Physiology

Frans Schuit, Jonathan E. Campbell
Journal: Diabetes
Diabetes 2023;72(9):1180–1183
https://doi.org/10.2337/dbi23-0014
Published: 21 August 2023
View article titled, GPCR Promiscuity Reshapes Islet Physiology
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Journal Articles

Bariatric Surgery Alters the Postprandial Recovery From Hypoglycemia, Mediated by Cholinergic Signal

Marzieh Salehi, Devjit Tripathy, Richard Peterson, Henri Honka, Samantha Pezzica, Ralph DeFronzo, Amalia Gastaldelli
Journal: Diabetes
Diabetes 2023;72(10):1374–1383
https://doi.org/10.2337/db23-0207
Published: 19 July 2023
View article titled, Bariatric Surgery Alters the Postprandial Recovery From Hypoglycemia, Mediated by Cholinergic Signal
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Journal Articles

Lysine 117 Residue Is Essential for the Function of the Hepatocyte Nuclear Factor 1α

Yuan Chu, Long Zhao, Xian Liu, Hui Chen, Chen Zhao, Sicong Chen, Shensi Xiang, Jun Lu, Xiaofang Wang, Yue Wan, Diandian Dong, Songhui Yao, Changyan Li, Ronghua Yin, Guangming Ren, Xiaoming Yang, Miao Yu
Journal: Diabetes
Diabetes 2023;72(10):1502–1516
https://doi.org/10.2337/db22-0672
Published: 13 July 2023
View article titled, Lysine 117 Residue Is Essential for the Function of the Hepatocyte Nuclear Factor 1α
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Journal Articles

Diurnal Cycling of Insulin Sensitivity in Type 2 Diabetes: Evidence for Deviation From Physiology at an Early Stage

Paola Lucidi, Gabriele Perriello, Francesca Porcellati, Simone Pampanelli, Michelantonio De Fano, Andrea Tura, Geremia B. Bolli, Carmine G. Fanelli
Journal: Diabetes
Diabetes 2023;72(10):1364–1373
https://doi.org/10.2337/db22-0721
Published: 13 July 2023
View article titled, Diurnal Cycling of Insulin Sensitivity in Type 2 Diabetes: Evidence for Deviation From Physiology at an Early Stage
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Journal Articles

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

Stephen E. Gitelman, Carmella Evans-Molina, Annamaria Guolo, Andrea Mari, Ele Ferrannini
Journal: Diabetes
Diabetes 2023;72(9):1289–1296
https://doi.org/10.2337/db23-0196
Published: 27 June 2023
View article titled, β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes
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Journal Articles

Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Yi-Chun Chen, Austin J. Taylor, James M. Fulcher, Adam C. Swensen, Xiao-Qing Dai, Mitsuhiro Komba, Kenzie L.C. Wrightson, Kenny Fok, Annette E. Patterson, Ramon I. Klein Geltink, Patrick E. MacDonald, Wei-Jun Qian, C. Bruce Verchere
Journal: Diabetes
Diabetes 2023;72(9):1277–1288
https://doi.org/10.2337/db22-0945
Published: 26 June 2023
View article titled, Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice
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Journal Articles

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Sean M. Peterson, Christine A. Juliana, Cameron F. Hu, Jinghua Chai, Carson Holliday, Kara Y. Chan, Ana G. Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, Ryan Stafford, Fumiko Axelrod, Tom Z. Yuan, Diva D. De León, Aaron K. Sato
Journal: Diabetes
Diabetes 2023;72(9):1320–1329
https://doi.org/10.2337/db22-1039
Published: 26 June 2023
View article titled, Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism
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Meeting Abstracts

179-OR: Improved A1C and TIR with Once-Weekly Insulin Icodec vs. Insulin Glargine U100 in Insulin-Naïve T2D—ONWARDS 1

JULIO ROSENSTOCK, STEPHEN C. BAIN, AMOOLYA GOWDA, HIROSHI HORIO, ESTEBAN JODAR, LARS LANG LEHRSKOV, ILDIKO LINGVAY, ROBERTO TREVISAN, OFRI MOSENZON
Journal: Diabetes
Diabetes 2023;72(Supplement_1):179-OR
https://doi.org/10.2337/db23-179-OR
Published: 24 June 2023
View article titled, 179-OR: Improved A1C and TIR with Once-Weekly Insulin Icodec vs. Insulin Glargine U100 in Insulin-Naïve T2D—ONWARDS 1
Meeting Abstracts

1803-PUB: Effectiveness and Safety of the Insulin Degludec U100 vs. Glargine U300 in People with Type 1 diabetes—The IneoxPlus Real-World Study

MARIA S. RUIZ DE ADANA, SR., MARTA E. DOMÍNGUEZ-LÓPEZ, MARÍA DEL ROSARIO VALLEJO MORA, NATALIA COLOMO, FRANCISCA LINARES, VIRGINIA MORILLAS, MARÍA JOSÉ VALLEJO HERRERA, SILVIA PATRICIA ALONSO GALLARDO, MARÍA TERESA PADILLA FUENTES, LUIS I. NAVAS VELA, CRISTINA MALDONADO-ARAQUE, GABRIEL OLVEIRA, GEMMA ROJO MARTÍNEZ
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1803-PUB
https://doi.org/10.2337/db23-1803-PUB
Published: 23 June 2023
View article titled, 1803-PUB: Effectiveness and Safety of the Insulin Degludec U100 vs. Glargine U300 in People with Type 1 diabetes—The IneoxPlus Real-World Study
Meeting Abstracts

1805-PUB: Results of a Two-Part Feasibility Study Assessing Inhaled Insulin for Meals with MDI or Automated Insulin Delivery (AID) Compared with Standard AID Therapy

KEVIN KAISERMAN, JOHANNA ULLOA, JENNIFER PLEITEZ, JOSEPH SYLVAN, KEVIN CODORNIZ, SCOTT LEE, CHRISTOPHER JACOBSON, THOMAS BLEVINS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1805-PUB
https://doi.org/10.2337/db23-1805-PUB
Published: 23 June 2023
View article titled, 1805-PUB: Results of a Two-Part Feasibility Study Assessing Inhaled Insulin for Meals with MDI or Automated Insulin Delivery (AID) Compared with Standard AID Therapy
Meeting Abstracts

1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs

ANNA GOOCH, CHRISTOF WESTENFELDER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1808-PUB
https://doi.org/10.2337/db23-1808-PUB
Published: 23 June 2023
View article titled, 1808-PUB: Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I.P. Administered “Neo-Islets,” 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells—The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs
Meeting Abstracts

1817-PUB: CGM-Derived Metrics and HbA1c in Adults with Type 2 Diabetes (T2D) on Different Insulin Treatment Regimens Not Meeting Glycemic Targets

NANNA LIND, MERETE B. CHRISTENSEN, KIRSTEN NØRGAARD
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1817-PUB
https://doi.org/10.2337/db23-1817-PUB
Published: 23 June 2023
View article titled, 1817-PUB: CGM-Derived Metrics and HbA1c in Adults with Type 2 Diabetes (T2D) on Different Insulin Treatment Regimens Not Meeting Glycemic Targets
Meeting Abstracts

178-OR: Better Glycemic Control with Once-Weekly Insulin Icodec vs. Once-Daily Insulin Degludec in Insulin-Naïve Type 2 Diabetes (ONWARDS 3)

ILDIKO LINGVAY, MARISSE ASONG, CYRUS DESOUZA, PIERRE GOURDY, SOUMITRA KAR, ANDRE G. VIANNA, TINA VILSBØLL, SIRI M. VINTHER, YIMING MU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):178-OR
https://doi.org/10.2337/db23-178-OR
Published: 23 June 2023
View article titled, 178-OR: Better Glycemic Control with Once-Weekly Insulin Icodec vs. Once-Daily Insulin Degludec in Insulin-Naïve Type 2 Diabetes (ONWARDS 3)
Meeting Abstracts

118-LB: Feasibility of a Prototype Dual Function Glucose Sensing Insulin Delivery Cannula in People with Type 1 Diabetes

JEAN LU, CHENG YI YUAN, YEE W. KONG, EMMA NETZER, HUANPING WU, THOMAS SEIDL, DAVID N. O'NEAL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):118-LB
https://doi.org/10.2337/db23-118-LB
Published: 23 June 2023
View article titled, 118-LB: Feasibility of a Prototype Dual Function Glucose Sensing Insulin Delivery Cannula in People with Type 1 Diabetes
Meeting Abstracts

836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

TREVOR W. REICHMAN, CAMILLO RICORDI, ALI NAJI, JAMES F. MARKMANN, BRUCE A. PERKINS, MARTIN WIJKSTROM, STEVEN PARASKEVAS, BOTE BRUINSMA, GAUTHAM MARIGOWDA, JUDY L. SHIH, CHENKUN WANG, DOUGLAS MELTON, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):836-P
https://doi.org/10.2337/db23-836-P
Published: 23 June 2023
View article titled, 836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial
Journal Articles

A Defect in Mitochondrial Complex III but Not in Complexes I or IV Causes Early β-Cell Dysfunction and Hyperglycemia in Mice

Anna L. Lang, Nadee Nissanka, Ruy A. Louzada, Alejandro Tamayo, Elizabeth Pereira, Carlos T. Moraes, Alejandro Caicedo
Journal: Diabetes
Diabetes 2023;72(9):1262–1276
https://doi.org/10.2337/db22-0728
Published: 21 June 2023
View article titled, A Defect in Mitochondrial Complex III but Not in Complexes I or IV Causes Early β-Cell Dysfunction and Hyperglycemia in Mice
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Journal Articles

Reciprocal Regulation of Hepatic TGF-β1 and Foxo1 Controls Gluconeogenesis and Energy Expenditure

Quan Pan, Weiqi Ai, Yunmei Chen, Da Mi Kim, Zheng Shen, Wanbao Yang, Wen Jiang, Yuxiang Sun, Stephen Safe, Shaodong Guo
Journal: Diabetes
Diabetes 2023;72(9):1193–1206
https://doi.org/10.2337/db23-0180
Published: 21 June 2023
View article titled, Reciprocal Regulation of Hepatic TGF-β1 and Foxo1 Controls Gluconeogenesis and Energy Expenditure
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Meeting Abstracts

975-P: Clinical and Lifestyle Determinants of Continuous Glucose Monitoring Metrics in Insulin-Treated Patients with Type 2 Diabetes

DA YOUNG LEE, NAMHO KIM, INHA JUNG, SO YOUNG PARK, JI HEE YU, JI A SEO, SUNG-MIN PARK, NAN HEE KIM
Journal: Diabetes
Diabetes 2023;72(Supplement_1):975-P
https://doi.org/10.2337/db23-975-P
Published: 20 June 2023
View article titled, 975-P: Clinical and Lifestyle Determinants of Continuous Glucose Monitoring Metrics in Insulin-Treated Patients with Type 2 Diabetes
Meeting Abstracts

1622-P: Complex Mechanisms Underlie the Antidiabetic Effect of Tempol in Experimentally Induced Diabetes Mellitus

YAHYA NAGUIB
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1622-P
https://doi.org/10.2337/db23-1622-P
Published: 20 June 2023
View article titled, 1622-P: Complex Mechanisms Underlie the Antidiabetic Effect of Tempol in Experimentally Induced Diabetes Mellitus