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Journal Articles

GPCR Promiscuity Reshapes Islet Physiology

Frans Schuit, Jonathan E. Campbell
Journal: Diabetes
Diabetes 2023;72(9):1180–1183
https://doi.org/10.2337/dbi23-0014
Published: 21 August 2023
View article titled, GPCR Promiscuity Reshapes Islet Physiology
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Journal Articles

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells

Sarah L. Armour, Alexander Frueh, Margarita V. Chibalina, Haiqiang Dou, Lidia Argemi-Muntadas, Alexander Hamilton, Georgios Katzilieris-Petras, Peter Carmeliet, Benjamin Davies, Thomas Moritz, Lena Eliasson, Patrik Rorsman, Jakob G. Knudsen
Journal: Diabetes
Diabetes 2023;72(10):1446–1459
https://doi.org/10.2337/db23-0056
Published: 26 July 2023
View article titled, Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells
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Journal Articles

Bariatric Surgery Alters the Postprandial Recovery From Hypoglycemia, Mediated by Cholinergic Signal

Marzieh Salehi, Devjit Tripathy, Richard Peterson, Henri Honka, Samantha Pezzica, Ralph DeFronzo, Amalia Gastaldelli
Journal: Diabetes
Diabetes 2023;72(10):1374–1383
https://doi.org/10.2337/db23-0207
Published: 19 July 2023
View article titled, Bariatric Surgery Alters the Postprandial Recovery From Hypoglycemia, Mediated by Cholinergic Signal
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Journal Articles

Diurnal Cycling of Insulin Sensitivity in Type 2 Diabetes: Evidence for Deviation From Physiology at an Early Stage

Paola Lucidi, Gabriele Perriello, Francesca Porcellati, Simone Pampanelli, Michelantonio De Fano, Andrea Tura, Geremia B. Bolli, Carmine G. Fanelli
Journal: Diabetes
Diabetes 2023;72(10):1364–1373
https://doi.org/10.2337/db22-0721
Published: 13 July 2023
View article titled, Diurnal Cycling of Insulin Sensitivity in Type 2 Diabetes: Evidence for Deviation From Physiology at an Early Stage
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Meeting Abstracts

5-LB: Rescuing Alpha-Cell Function in Type 1 Diabetes

JULIA PANZER, ALBERTO PUGLIESE
Journal: Diabetes
Diabetes 2023;72(Supplement_1):5-LB
https://doi.org/10.2337/db23-5-LB
Published: 20 June 2023
View article titled, 5-LB: Rescuing Alpha-Cell Function in Type 1 Diabetes
Meeting Abstracts

36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes

AOIFE M. EGAN, MAYA ZEINI, ANDREW A. WELCH, RAHELE A. FARAHANI, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):36-OR
https://doi.org/10.2337/db23-36-OR
Published: 20 June 2023
View article titled, 36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes
Meeting Abstracts

244-OR: Signs of Glucagon Resistance after a Two-Week Hypercaloric Diet Intervention

MALTE P. SUPPLI, JONATAN I. BAGGER, SR., JENS J. HOLST, FILIP K. KNOP
Journal: Diabetes
Diabetes 2023;72(Supplement_1):244-OR
https://doi.org/10.2337/db23-244-OR
Published: 20 June 2023
View article titled, 244-OR: Signs of Glucagon Resistance after a Two-Week Hypercaloric Diet Intervention
Meeting Abstracts

1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

GUILLAUME KRAFT, MELANIE SCOTT, MARTA S. SMITH, BEN FARMER, DALE S. EDGERTON, ALAN D. CHERRINGTON
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1560-P
https://doi.org/10.2337/db23-1560-P
Published: 20 June 2023
View article titled, 1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin
Meeting Abstracts

1301-P: Glucagon Stimulation Test—Is It Time for an Easy Interpretation Proposal?

ALESSANDRO RIZZI, LINDA TARTAGLIONE, SHAWN GUGLIANDOLO, ENRICO DI STASIO, ANNARITA BARBERIO, DARIO PITOCCO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1301-P
https://doi.org/10.2337/db23-1301-P
Published: 20 June 2023
View article titled, 1301-P: Glucagon Stimulation Test—Is It Time for an Easy Interpretation Proposal?
Meeting Abstracts

245-LB: Glucagon Infusion into the Mediobasal Hypothalamus Lowers Hepatic Triglyceride Secretion

MANTASH S. GREWAL, BOYAN VASILEV, CARRIE-LYNN M. SOLTYS, BRYAN LUM, JESSICA T. YUE
Journal: Diabetes
Diabetes 2023;72(Supplement_1):245-LB
https://doi.org/10.2337/db23-245-LB
Published: 20 June 2023
View article titled, 245-LB: Glucagon Infusion into the Mediobasal Hypothalamus Lowers Hepatic Triglyceride Secretion
Meeting Abstracts

1022-P: Trends in Glucagon Fill Rates among U.S. Adults with Diabetes and End-Stage Kidney Disease on Dialysis

RODOLFO J. GALINDO, SHEALEIGH INSELMAN, BOBAK MOAZZAMI, MOHAMMED K. ALI, GUILLERMO UMPIERREZ, ROZALINA G. MCCOY
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1022-P
https://doi.org/10.2337/db23-1022-P
Published: 20 June 2023
View article titled, 1022-P: Trends in Glucagon Fill Rates among U.S. Adults with Diabetes and End-Stage Kidney Disease on Dialysis
Meeting Abstracts

130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice

BUKYUNG KIM, LAUREN A. TAUER, XIAODI HU, JASON K. KIM
Journal: Diabetes
Diabetes 2023;72(Supplement_1):130-OR
https://doi.org/10.2337/db23-130-OR
Published: 20 June 2023
View article titled, 130-OR: Tirzepatide Attenuates Hepatic Insulin Resistance and Glucagon Action Independent of Weight Loss and GIP Action in Diet-Induced Obese Mice
Meeting Abstracts

871-P: Study of Glucagon Response and Its Association with Glycemic Control and Ketogenesis after Administration of Ipragliflozin as an Adjunctive Treatment in Patients with Type 1 Diabetes (Suglat-AID)—A Multicenter, Open-Label, Prospective Exploratory Trial

YUTA NAKAMURA, ICHIRO HORIE, NORIO ABIRU, TADAHIRO KITAMURA, YOSHIKI KUSUNOKI, KENRO NISHIDA, AKANE YAMAMOTO, YUSHI HIROTA, TOMOYASU FUKUI, YASUTAKA MAEDA, MASAE MINAMI, TAKANORI MATSUI, ATSUSHI KAWAKAMI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):871-P
https://doi.org/10.2337/db23-871-P
Published: 20 June 2023
View article titled, 871-P: Study of Glucagon Response and Its Association with Glycemic Control and Ketogenesis after Administration of Ipragliflozin as an Adjunctive Treatment in Patients with Type 1 Diabetes (Suglat-AID)—A Multicenter, Open-Label, Prospective Exploratory Trial
Meeting Abstracts

34-OR: Postprandial Glucagon Action in the Human Brain

ROBERT WAGNER, STEPHANIE KULLMANN, JULIA HUMMEL, RALF VEIT, KATSIARYNA PRYSTUPA, ELENA HOSENFELD, ANDREAS L. BIRKENFELD, HANS-ULRICH HÄRING, HUBERT PREISSL, ANDREAS FRITSCHE, ANDREAS PETER, MARTIN HENI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):34-OR
https://doi.org/10.2337/db23-34-OR
Published: 20 June 2023
View article titled, 34-OR: Postprandial Glucagon Action in the Human Brain
Meeting Abstracts

240-OR: Islet Allotransplantation into Prevascularized Sernova Cell Pouch—Early Results from the University of Chicago

MATEUSZ OGLEDZINSKI, SARAH GONDEK, WILLIAM LIN, KAMILA MILEJCZYK, BRADEN JUENGEL, LISA POTTER, PIOTR J. BACHUL, LINDSAY BASTO, LAURENCIA PEREA, LINGJIA WANG, MARTIN TIBUDAN, ROLF BARTH, JOHN FUNG, PIOTR WITKOWSKI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):240-OR
https://doi.org/10.2337/db23-240-OR
Published: 20 June 2023
View article titled, 240-OR: Islet Allotransplantation into Prevascularized Sernova Cell Pouch—Early Results from the University of Chicago
Meeting Abstracts

77-LB: A Novel Glucagon-Like Peptide-1 (GLP-1R) and Glucagon (GCGR) Receptor Dual Agonist, Mazdutide (IBI362), Attenuates Hyperuricemia in Hyperuricemic Rats

HONGWEI JIANG, YANZHAO ZHANG, YAN SHUANG REN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):77-LB
https://doi.org/10.2337/db23-77-LB
Published: 20 June 2023
View article titled, 77-LB: A Novel Glucagon-Like Peptide-1 (GLP-1R) and Glucagon (GCGR) Receptor Dual Agonist, Mazdutide (IBI362), Attenuates Hyperuricemia in Hyperuricemic Rats
Meeting Abstracts

21-OR: Insulin and Glucagon Regulate a Novel Bidirectional Long Noncoding RNA/Protein-Coding Gene Pair That Control Cell Sensitivity to Metabolic Stress

XIANGYU LIU, C. RONALD KAHN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):21-OR
https://doi.org/10.2337/db23-21-OR
Published: 20 June 2023
View article titled, 21-OR: Insulin and Glucagon Regulate a Novel Bidirectional Long Noncoding RNA/Protein-Coding Gene Pair That Control Cell Sensitivity to Metabolic Stress
Meeting Abstracts

219-OR: Glucagon Counterregulation in a Hypoglycemic Clamp in Type 1 Diabetes Is Increased by ZT-01, a Novel Somatostatin Receptor 2 Antagonist—A Phase 1b Study

ALEXANDER ABITBOL, SUSAN PEERS, ERIC SIMONSON, MICHAEL MIDMER, MICHAEL RIDDELL, RICHARD LIGGINS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):219-OR
https://doi.org/10.2337/db23-219-OR
Published: 20 June 2023
View article titled, 219-OR: Glucagon Counterregulation in a Hypoglycemic Clamp in Type 1 Diabetes Is Increased by ZT-01, a Novel Somatostatin Receptor 2 Antagonist—A Phase 1b Study
Meeting Abstracts

1593-P: Insulin-Degrading Enzyme (IDE) Regulates Glucagon Signalling and Mitochondrial Respiration in Hepatocytes

CARLOS M. GONZÁLEZ-CASIMIRO, PATRICIA CÁMARA-TORRES, BEATRIZ MERINO, JAIME SANTO-DOMINGO, MIGUEL A. DE LA FUENTE, ANDRÉS ALONSO, IRENE COZAR-CASTELLANO, GERMAN PERDOMO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1593-P
https://doi.org/10.2337/db23-1593-P
Published: 20 June 2023
View article titled, 1593-P: Insulin-Degrading Enzyme (IDE) Regulates Glucagon Signalling and Mitochondrial Respiration in Hepatocytes
Meeting Abstracts

1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules

WILLIAM ROELL, AJIT REGMI, CHARLES T. BENSON, TAMER COSKUN, JULIE S. MOYERS, JORGE ALSINA-FERNANDEZ, MELISSA K. THOMAS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1588-P
https://doi.org/10.2337/db23-1588-P
Published: 20 June 2023
View article titled, 1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules