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Meeting Abstracts

1279-P: The INNODIA Natural History Study of Children, Adolescents, and Adults Newly Diagnosed with Type 1 Diabetes

M. LOREDANA MARCOVECCHIO, CARL DELFIN, MARGO HULSMANS, LUTGART OVERBERGH, SOFIA S. PAZMINO, DIANE E. PICTON, NELE STEENACKERS, BART VAN DER SCHUEREN, ALLAIRD E.J. HENDRIKS, CHANTAL MATHIEU, INNODIA CONSORTIUM

Diabetes 2023;72(Supplement_1):1279-P

https://doi.org/10.2337/db23-1279-P

Published: 20 June 2023

View article titled, 1279-P: The INNODIA Natural History Study of Children, Adolescents, and Adults Newly Diagnosed with Type 1 Diabetes

Meeting Abstracts

1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

EMILY K. SIMS, DAVID D. CUTHBERTSON, EMANUELE BOSI, CARMELLA EVANS-MOLINA, MARIA J. REDONDO, BRANDON M. NATHAN, HEBA M. ISMAIL, LAURA M. JACOBSEN, JAY SOSENKO

Diabetes 2023;72(Supplement_1):1441-P

https://doi.org/10.2337/db23-1441-P

Published: 20 June 2023

View article titled, 1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

Meeting Abstracts

300-OR: Stage Transitions in Preclinical Type 1 Diabetes—Protective Effect of IA2 Variant Autoantibody Positivity

CRAIG BEAM, SUSAN PIETROPAOLO, MARIA J. ACEVEDO-CALADO, MARK A. HERMAN, MARIA J. REDONDO, MASSIMO PIETROPAOLO

Diabetes 2023;72(Supplement_1):300-OR

https://doi.org/10.2337/db23-300-OR

Published: 20 June 2023

View article titled, 300-OR: Stage Transitions in Preclinical Type 1 Diabetes—Protective Effect of IA2 Variant Autoantibody Positivity

Meeting Abstracts

1463-P: Heterozygous Variant in NFKB1 Presenting with Autoantibody-Negative (AbNeg) Insulin-Dependent Diabetes (IDDM)

MARIA J. REDONDO, PENGFEI LIU, AHMED N. ALKANAQ, MUSTAFA TOSUR, NALINI RAM, RAYMOND J. KREIENKAMP, ELIF A. ORAL, CATHERINE PIHOKER, JENNIFER POSEY, ASHOK BALASUBRAMANYAM

Diabetes 2023;72(Supplement_1):1463-P

https://doi.org/10.2337/db23-1463-P

Published: 20 June 2023

View article titled, 1463-P: Heterozygous Variant in NFKB1 Presenting with Autoantibody-Negative (AbNeg) Insulin-Dependent Diabetes (IDDM)

Meeting Abstracts

1308-P: Glutamic Acid Decarboxylase Autoantibodies (GADA) in Type 2 Diabetes Do Not Predict Long-Term Diabetes Complications

SCOTT J. PILLA, WILLIAM C. KNOWLER, ASHOK BALASUBRAMANYAM, CHRISTIANE S. HAMPE, SUSAN PIETROPAOLO, ANDREA M. ANDERSON, MO LI, NI ZHAO, SCOTT L. ZEGER, ANITA RAMELIUS, RASMUS BENNET, ÅKE LERNMARK, NESTORAS N. MATHIOUDAKIS, JEANNE CLARK, NISA M. MARUTHUR

Diabetes 2023;72(Supplement_1):1308-P

https://doi.org/10.2337/db23-1308-P

Published: 20 June 2023

View article titled, 1308-P: Glutamic Acid Decarboxylase Autoantibodies (GADA) in Type 2 Diabetes Do Not Predict Long-Term Diabetes Complications

Meeting Abstracts

1425-P: C-Peptide and Islet Autoantibodies at Diagnosis Predict Long-Term ß-Cell Function and Insulin Dependence in Pediatric Diabetes

MUSTAFA TOSUR, XIAOFAN C. HUANG, SAIMA DEEN, SERIFE UYSAL, MARCELA ASTUDILLO, WILLIAM HAGOPIAN, RICHARD A. ORAM, FAROOK JAHOOR, MARIA J. REDONDO, ASHOK BALASUBRAMANYAM

Diabetes 2023;72(Supplement_1):1425-P

https://doi.org/10.2337/db23-1425-P

Published: 20 June 2023

View article titled, 1425-P: C-Peptide and Islet Autoantibodies at Diagnosis Predict Long-Term ß-Cell Function and Insulin Dependence in Pediatric Diabetes

Meeting Abstracts

1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

MARIA J. REDONDO, KYLIE K. HARRALL, DEBORAH H. GLUECK, MUSTAFA TOSUR, SERIFE UYSAL, ANDREW MUIR, KENDRA VEHIK, TODD M. BRUSKO, MARK A. ATKINSON, RICHARD A. ORAM, DANA DABELEA, WILLIAM HAGOPIAN, DISCOVER STUDY GROUP

Diabetes 2023;72(Supplement_1):1298-P

https://doi.org/10.2337/db23-1298-P

Published: 20 June 2023

View article titled, 1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

Meeting Abstracts

205-OR: Automated Multiplex Antibody Detection by Agglutination PCR (ADAP) Compared with Gold Standard Radiobinding Assays of Autoantibodies in Type 1 Diabetes

ALEXANDER LIND, ANITA RAMELIUS, EVA FREYHULT, FELIPE DE JESUS CORTEZ, RASMUS BENNET, HELENA E. LARSSON, DAVID SEFTEL, JASON TSAI, ÅKE LERNMARK

Diabetes 2023;72(Supplement_1):205-OR

https://doi.org/10.2337/db23-205-OR

Published: 20 June 2023

View article titled, 205-OR: Automated Multiplex Antibody Detection by Agglutination PCR (ADAP) Compared with Gold Standard Radiobinding Assays of Autoantibodies in Type 1 Diabetes

Meeting Abstracts

174-LB: Autoantibodies against PTM-IA2 Extracellular Domain Are Only Associated with Late Progression of Type 1 Diabetes

XIAOFAN JIA, JANET M. WENZLAU, MARIAN REWERS, AARON W. MICHELS, LIPING YU

Diabetes 2023;72(Supplement_1):174-LB

https://doi.org/10.2337/db23-174-LB

Published: 20 June 2023

View article titled, 174-LB: Autoantibodies against PTM-IA2 Extracellular Domain Are Only Associated with Late Progression of Type 1 Diabetes

Meeting Abstracts

198-LB: Dynamic Behavior of Healthy People with Different Numbers of Autoantibodies

ESLAM MONTASER, MARC D. BRETON, SUE A. BROWN, MARK D. DEBOER, ANTHONY L. MCCALL, BORIS KOVATCHEV, LEON FARHY

Diabetes 2023;72(Supplement_1):198-LB

https://doi.org/10.2337/db23-198-LB

Published: 20 June 2023

View article titled, 198-LB: Dynamic Behavior of Healthy People with Different Numbers of Autoantibodies

Meeting Abstracts

634-P: Autoantibody Screening Attitudes and Experiences in People Affected by Type 1 Diabetes

CAITLIN S. KELLY, KATHERINE S.M. CHAPMAN, JESSICA L. DUNNE, EMILEE M. CORNELIUS, MEGAN PETER, ELLEN PAGAN INDOE, WENDY WOLF

Diabetes 2023;72(Supplement_1):634-P

https://doi.org/10.2337/db23-634-P

Published: 20 June 2023

View article titled, 634-P: Autoantibody Screening Attitudes and Experiences in People Affected by Type 1 Diabetes

Meeting Abstracts

1445-P: A Glucose Fraction Independent of Insulin Secretion in Autoantibody Positive (Ab+) Individuals

JAY SOSENKO, DAVID D. CUTHBERTSON, MARIA J. REDONDO, HEBA M. ISMAIL, EMILY K. SIMS, LAURA M. JACOBSEN, BRANDON M. NATHAN

Diabetes 2023;72(Supplement_1):1445-P

https://doi.org/10.2337/db23-1445-P

Published: 20 June 2023

View article titled, 1445-P: A Glucose Fraction Independent of Insulin Secretion in Autoantibody Positive (Ab+) Individuals

Meeting Abstracts

1273-P: Guidance to Persons Who Screen Positive for Islet Autoantibodies and Their Health Care Providers—Ask the Experts

KIMBER M. SIMMONS, KIMBERLY A. BAUTISTA, CRISTY GENO RASMUSSEN, RACHEL KARBAN, HOLLY K. O'DONNELL, BRIGITTE I. FROHNERT, ANDREA STECK, MARIAN REWERS

Diabetes 2023;72(Supplement_1):1273-P

https://doi.org/10.2337/db23-1273-P

Published: 20 June 2023

View article titled, 1273-P: Guidance to Persons Who Screen Positive for Islet Autoantibodies and Their Health Care Providers—Ask the Experts

Meeting Abstracts

197-LB: Capillary Islet Autoantibody Testing at the Preschool Vaccination Is a Feasible and Acceptable Method to Screen Children for Type 1 Diabetes

CLAIRE SCUDDER, JANE BOWEN-MORRIS, PHILIP H. EVANS, SARAH C. JONES, NICHOLAS P.B. THOMAS, ROBIN FOX, JOHN TODD, SHEILA GREENFIELD, COLIN DAYAN, JULIA TOWNSON, RACHEL BESSER

Diabetes 2023;72(Supplement_1):197-LB

https://doi.org/10.2337/db23-197-LB

Published: 20 June 2023

View article titled, 197-LB: Capillary Islet Autoantibody Testing at the Preschool Vaccination Is a Feasible and Acceptable Method to Screen Children for Type 1 Diabetes

Meeting Abstracts

20-OR: Loss of Characteristic ß-Cell Function in Autoantibody-Positive (Ab+) Individuals during the Progression to Type 1 Diabetes (T1D)

HEBA M. ISMAIL, DAVID D. CUTHBERTSON, JAY S. SKYLER, CARMELLA EVANS-MOLINA, JAY SOSENKO

Diabetes 2023;72(Supplement_1):20-OR

https://doi.org/10.2337/db23-20-OR

Published: 20 June 2023

View article titled, 20-OR: Loss of Characteristic ß-Cell Function in Autoantibody-Positive (Ab+) Individuals during the Progression to Type 1 Diabetes (T1D)

Meeting Abstracts

1388-P: Clinical Features Associated with Glutamic Acid Decarboxylase Autoantibodies (GADA) in Adults with Type 2 Diabetes

Diabetes 2023;72(Supplement_1):1388-P

https://doi.org/10.2337/db23-1388-P

Published: 20 June 2023

View article titled, 1388-P: Clinical Features Associated with Glutamic Acid Decarboxylase Autoantibodies (GADA) in Adults with Type 2 Diabetes

Meeting Abstracts

1387-P: Glutamic Acid Decarboxylase Autoantibodies (GADA) in Type 2 Diabetes Predict Glycemic Control over 16 Years

Diabetes 2023;72(Supplement_1):1387-P

https://doi.org/10.2337/db23-1387-P

Published: 20 June 2023

View article titled, 1387-P: Glutamic Acid Decarboxylase Autoantibodies (GADA) in Type 2 Diabetes Predict Glycemic Control over 16 Years

Meeting Abstracts

668-P: Exploring Attitudes toward Autoantibody Screening in People Living with T1D, Caregivers, and First-Degree Relatives

MEGAN PETER, KATHERINE S.M. CHAPMAN, JESSICA L. DUNNE, CAITLIN S. KELLY, WENDY WOLF

Diabetes 2023;72(Supplement_1):668-P

https://doi.org/10.2337/db23-668-P

Published: 20 June 2023

View article titled, 668-P: Exploring Attitudes toward Autoantibody Screening in People Living with T1D, Caregivers, and First-Degree Relatives

Meeting Abstracts

190-LB: Differences in Postprandial and Counterregulatory Glucagon Excursions in Healthy Relatives to Type 1 Diabetes with Different Number of Islet Autoantibodies

TOBORE IGBE, ESLAM MONTASER, MARC D. BRETON, SUE A. BROWN, MARK D. DEBOER, ANTHONY L. MCCALL, BORIS KOVATCHEV, LEON FARHY

Diabetes 2023;72(Supplement_1):190-LB

https://doi.org/10.2337/db23-190-LB

Published: 20 June 2023

View article titled, 190-LB: Differences in Postprandial and Counterregulatory Glucagon Excursions in Healthy Relatives to Type 1 Diabetes with Different Number of Islet Autoantibodies

Meeting Abstracts

1451-P: Risk of Progression to Clinical Type 1 Diabetes in Older Adolescents Positive for Islet Autoantibodies

KATHLEEN WAUGH, CRISTY GENO RASMUSSEN, FRAN DONG, PATRICIA D. GESUALDO, BRIGITTE I. FROHNERT, MARIAN REWERS

Diabetes 2023;72(Supplement_1):1451-P

https://doi.org/10.2337/db23-1451-P

Published: 20 June 2023

View article titled, 1451-P: Risk of Progression to Clinical Type 1 Diabetes in Older Adolescents Positive for Islet Autoantibodies

NARROW

1279-P: The INNODIA Natural History Study of Children, Adolescents, and Adults Newly Diagnosed with Type 1 Diabetes

1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

300-OR: Stage Transitions in Preclinical Type 1 Diabetes—Protective Effect of IA2 Variant Autoantibody Positivity

1463-P: Heterozygous Variant in NFKB1 Presenting with Autoantibody-Negative (AbNeg) Insulin-Dependent Diabetes (IDDM)

1308-P: Glutamic Acid Decarboxylase Autoantibodies (GADA) in Type 2 Diabetes Do Not Predict Long-Term Diabetes Complications

1425-P: C-Peptide and Islet Autoantibodies at Diagnosis Predict Long-Term ß-Cell Function and Insulin Dependence in Pediatric Diabetes

1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

205-OR: Automated Multiplex Antibody Detection by Agglutination PCR (ADAP) Compared with Gold Standard Radiobinding Assays of Autoantibodies in Type 1 Diabetes

174-LB: Autoantibodies against PTM-IA2 Extracellular Domain Are Only Associated with Late Progression of Type 1 Diabetes

198-LB: Dynamic Behavior of Healthy People with Different Numbers of Autoantibodies

634-P: Autoantibody Screening Attitudes and Experiences in People Affected by Type 1 Diabetes

1445-P: A Glucose Fraction Independent of Insulin Secretion in Autoantibody Positive (Ab+) Individuals

1273-P: Guidance to Persons Who Screen Positive for Islet Autoantibodies and Their Health Care Providers—Ask the Experts

197-LB: Capillary Islet Autoantibody Testing at the Preschool Vaccination Is a Feasible and Acceptable Method to Screen Children for Type 1 Diabetes

20-OR: Loss of Characteristic ß-Cell Function in Autoantibody-Positive (Ab+) Individuals during the Progression to Type 1 Diabetes (T1D)

1388-P: Clinical Features Associated with Glutamic Acid Decarboxylase Autoantibodies (GADA) in Adults with Type 2 Diabetes

1387-P: Glutamic Acid Decarboxylase Autoantibodies (GADA) in Type 2 Diabetes Predict Glycemic Control over 16 Years

668-P: Exploring Attitudes toward Autoantibody Screening in People Living with T1D, Caregivers, and First-Degree Relatives

190-LB: Differences in Postprandial and Counterregulatory Glucagon Excursions in Healthy Relatives to Type 1 Diabetes with Different Number of Islet Autoantibodies

1451-P: Risk of Progression to Clinical Type 1 Diabetes in Older Adolescents Positive for Islet Autoantibodies

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