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Journal Articles

Induction of KLF2 by Exercise Activates eNOS to Improve Vasodilatation in Diabetic Mice

Jiang-Yun Luo, Chak Kwong Cheng, Lingshan Gou, Lei He, Lei Zhao, Yang Zhang, Li Wang, Chi Wai Lau, Aimin Xu, Alex F. Chen, Yu Huang
Journal: Diabetes
Diabetes 2023;72(9):1330–1342
https://doi.org/10.2337/db23-0070
Published: 22 June 2023
View article titled, Induction of KLF2 by Exercise Activates eNOS to Improve Vasodilatation in Diabetic Mice
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Journal Articles

Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization

Lei Zhao, Cheng-Lin Zhang, Lei He, Qinghua Chen, Limei Liu, Lijing Kang, Jian Liu, Jiang-Yun Luo, Lingshan Gou, Dan Qu, Wencong Song, Chi Wai Lau, Ho Ko, Vincent C.T. Mok, Xiao Yu Tian, Li Wang, Yu Huang
Journal: Diabetes
Diabetes 2022;71(5):1099–1114
https://doi.org/10.2337/db21-0660
Published: 18 February 2022
View article titled, Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization
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Journal Articles

Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1

Zhen Guo, Yixuan Zhang, Chang Liu, Ji Youn Youn, Hua Cai
Journal: Diabetes
Diabetes 2021;70(9):2107–2119
https://doi.org/10.2337/db20-0591
Published: 14 June 2021
View article titled, Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1
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Meeting Abstracts

64-OR: Metformin Improves Cardiac and Aortic Parameters in Adolescents with Type 1 Diabetes

ALEXANDER NGUYEN, UYEN TRUONG, MICHAL SCHAFER, AMY BAUMGARTNER, ALEX J. BARKER, KENDALL S. HUNTER, DALE BURKETT, JANE E. REUSCH, KRISTEN J. NADEAU
Journal: Diabetes
Diabetes 2021;70(Supplement_1):64-OR
https://doi.org/10.2337/db21-64-OR
Published: 01 June 2021
View article titled, 64-OR: Metformin Improves Cardiac and Aortic Parameters in Adolescents with Type 1 Diabetes
Journal Articles

Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis

Arpeeta Sharma, Judy S.Y. Choi, Nada Stefanovic, Annas Al-Sharea, Daniel S. Simpson, Nigora Mukhamedova, Karin Jandeleit-Dahm, Andrew J. Murphy, Dmitri Sviridov, James E. Vince, Rebecca H. Ritchie, Judy B. de Haan
Journal: Diabetes
Diabetes 2021;70(3):772–787
https://doi.org/10.2337/db20-0357
Published: 15 December 2020
View article titled, Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis
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Journal Articles

PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment

Longhua Liu, Lihong Fan, Michelle Chan, Michael J. Kraakman, Jing Yang, Yong Fan, Nicole Aaron, Qianfen Wan, Maria Alicia Carrillo-Sepulveda, Alan R. Tall, Ira Tabas, Domenico Accili, Li Qiang
Journal: Diabetes
Diabetes 2020;69(8):1793–1803
https://doi.org/10.2337/db20-0217
Published: 14 May 2020
View article titled, PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment
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Journal Articles

CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes

Cheng Wang, Yuelin Chao, Wenjing Xu, Minglu Liang, Shan Deng, Donghong Zhang, Kai Huang
Journal: Diabetes
Diabetes 2020;69(1):99–111
https://doi.org/10.2337/db19-0635
Published: 01 November 2019
View article titled, CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes
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Includes: Supplementary data
Journal Articles

Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis

Eoin P. Brennan, Muthukumar Mohan, Aaron McClelland, Monica de Gaetano, Christos Tikellis, Mariam Marai, Daniel Crean, Aozhi Dai, Ophelie Beuscart, Sinda Derouiche, Stephen P. Gray, Raelene Pickering, Sih Min Tan, Molly Godson-Treacy, Stephen Sheehan, Joseph F. Dowdall, Mary Barry, Orina Belton, Syed Tasadaque Ali-Shah, Patrick J. Guiry, Karin Jandeleit-Dahm, Mark E. Cooper, Catherine Godson, Phillip Kantharidis
Journal: Diabetes
Diabetes 2018;67(12):2657–2667
https://doi.org/10.2337/db17-1317
Published: 13 September 2018
View article titled, Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis
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Includes: Supplementary data
Journal Articles

Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1)

Jiaze Li, Pacific Huynh, Aozhi Dai, Tieqiao Wu, Yugang Tu, Bryna Chow, Helen Kiriazis, Xiao-Jun Du, Leon A. Bach, Jennifer L. Wilkinson-Berka, Erik Biros, Philip Walker, Maria Nataatmadja, Malcolm West, Jonathan Golledge, Terri J. Allen, Mark E. Cooper, Zhonglin Chai
Journal: Diabetes
Diabetes 2018;67(4):755–768
https://doi.org/10.2337/db17-0134
Published: 08 January 2018
View article titled, Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1)
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Includes: Supplementary data
Journal Articles

Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase–Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance

Nicole T. Watt, Matthew C. Gage, Peysh A. Patel, Hema Viswambharan, Piruthivi Sukumar, Stacey Galloway, Nadira Y. Yuldasheva, Helen Imrie, Andrew M.N. Walker, Kathryn J. Griffin, Natalia Makava, Anna Skromna, Katherine Bridge, David J. Beech, Stéphane Schurmans, Stephen B. Wheatcroft, Mark T. Kearney, Richard M. Cubbon
Journal: Diabetes
Diabetes 2017;66(11):2808–2821
https://doi.org/10.2337/db17-0062
Published: 22 August 2017
View article titled, Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase–Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance
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Includes: Supplementary data
Journal Articles

PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice

Wai San Cheang, Wing Tak Wong, Lei Zhao, Jian Xu, Li Wang, Chi Wai Lau, Zhen Yu Chen, Ronald Ching Wan Ma, Aimin Xu, Nanping Wang, Xiao Yu Tian, Yu Huang
Journal: Diabetes
Diabetes 2017;66(2):519–528
https://doi.org/10.2337/db15-1657
Published: 17 November 2016
View article titled, PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice
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Includes: Supplementary data
Journal Articles

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

Qilong Wang, Miao Zhang, Gloria Torres, Shengnan Wu, Changhan Ouyang, Zhonglin Xie, Ming-Hui Zou
Journal: Diabetes
Diabetes 2017;66(1):193–205
https://doi.org/10.2337/db16-0915
Published: 13 October 2016
View article titled, Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
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Includes: Supplementary data
Journal Articles

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

Liping Xie, Yue Gu, Mingliang Wen, Shuang Zhao, Wan Wang, Yan Ma, Guoliang Meng, Yi Han, Yuhui Wang, George Liu, Philip K. Moore, Xin Wang, Hong Wang, Zhiren Zhang, Ying Yu, Albert Ferro, Zhengrong Huang, Yong Ji
Journal: Diabetes
Diabetes 2016;65(10):3171–3184
https://doi.org/10.2337/db16-0020
Published: 22 June 2016
View article titled, Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation
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Includes: Supplementary data
Journal Articles

Inhibition of miR-200c Restores Endothelial Function in Diabetic Mice Through Suppression of COX-2

Huina Zhang, Jian Liu, Dan Qu, Li Wang, Jiang-Yun Luo, Chi Wai Lau, Pingsheng Liu, Zhen Gao, George L. Tipoe, Hung Kay Lee, Chi Fai Ng, Ronald Ching Wan Ma, Xiaoqiang Yao, Yu Huang
Journal: Diabetes
Diabetes 2016;65(5):1196–1207
https://doi.org/10.2337/db15-1067
Published: 28 January 2016
View article titled, Inhibition of miR-200c Restores Endothelial Function in Diabetic Mice Through Suppression of COX-2
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Includes: Supplementary data
Journal Articles

Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis

Arpeeta Sharma, Stephanie Sellers, Nada Stefanovic, Cleo Leung, Sih Min Tan, Olivier Huet, David J. Granville, Mark E. Cooper, Judy B. de Haan, Pascal Bernatchez
Journal: Diabetes
Diabetes 2015;64(11):3937–3950
https://doi.org/10.2337/db15-0472
Published: 26 June 2015
View article titled, Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis
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Includes: Supplementary data
Journal Articles

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1

Chaoyong He, Hongliang Li, Benoit Viollet, Ming-Hui Zou, Zhonglin Xie
Journal: Diabetes
Diabetes 2015;64(12):4285–4297
https://doi.org/10.2337/db15-0107
Published: 09 April 2015
View article titled, AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1
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Includes: Supplementary data
Journal Articles

Unconjugated Bilirubin Mediates Heme Oxygenase-1–Induced Vascular Benefits in Diabetic Mice

Jian Liu, Li Wang, Xiao Yu Tian, Limei Liu, Wing Tak Wong, Yang Zhang, Quan-Bin Han, Hing-Man Ho, Nanping Wang, Siu Ling Wong, Zhen-Yu Chen, Jun Yu, Chi-Fai Ng, Xiaoqiang Yao, Yu Huang
Journal: Diabetes
Diabetes 2015;64(5):1564–1575
https://doi.org/10.2337/db14-1391
Published: 04 December 2014
View article titled, Unconjugated Bilirubin Mediates Heme Oxygenase-1–Induced Vascular Benefits in Diabetic Mice
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Includes: Supplementary data
Journal Articles

Targeted Reduction of Vascular Msx1 and Msx2 Mitigates Arteriosclerotic Calcification and Aortic Stiffness in LDLR-Deficient Mice Fed Diabetogenic Diets

Su-Li Cheng, Abraham Behrmann, Jian-Su Shao, Bindu Ramachandran, Karen Krchma, Yoanna Bello Arredondo, Attila Kovacs, Megan Mead, Robert Maxson, Dwight A. Towler
Journal: Diabetes
Diabetes 2014;63(12):4326–4337
https://doi.org/10.2337/db14-0326
Published: 13 November 2014
View article titled, Targeted Reduction of Vascular <em>Msx1</em> and <em>Msx2</em> Mitigates Arteriosclerotic Calcification and Aortic Stiffness in <em>LDLR</em>-Deficient Mice Fed Diabetogenic Diets
Open the PDF for Targeted Reduction of Vascular <em>Msx1</em> and <em>Msx2</em> Mitigates Arteriosclerotic Calcification and Aortic Stiffness in <em>LDLR</em>-Deficient Mice Fed Diabetogenic Diets in another window
Includes: Supplementary data
Journal Articles

Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation

Zhongjian Cheng, Xiaohua Jiang, Meghana Pansuria, Pu Fang, Jietang Mai, Karthik Mallilankaraman, Rajesh Kumar Gandhirajan, Satoru Eguchi, Rosario Scalia, Muniswamy Madesh, Xiaofeng Yang, Hong Wang
Journal: Diabetes
Diabetes 2015;64(3):947–959
https://doi.org/10.2337/db14-0784
Published: 28 October 2014
View article titled, Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation
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Includes: Supplementary data
Journal Articles

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

Chris Tikellis, Raelene J. Pickering, Despina Tsorotes, Olivier Huet, Mark E. Cooper, Karin Jandeleit-Dahm, Merlin C. Thomas
Journal: Diabetes
Diabetes 2014;63(11):3915–3925
https://doi.org/10.2337/db13-0932
Published: 13 October 2014
View article titled, Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes
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