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Meeting Abstracts

1601-P: Childhood Plasma Amino Acid Profiles Predict the 10-Year Risk of Nonalcoholic Fatty Liver Disease—The BCAMS Study

MING LI, SHAN GAO, BCAMS GROUP

Diabetes 2023;72(Supplement_1):1601-P

https://doi.org/10.2337/db23-1601-P

Published: 20 June 2023

View article titled, 1601-P: Childhood Plasma Amino Acid Profiles Predict the 10-Year Risk of Nonalcoholic Fatty Liver Disease—The BCAMS Study

Meeting Abstracts

1099-P: Plasma Amino Acid Profiles in Childhood Predict 10-Year Risk of Insulin Resistance in Adulthood—The BCAMS Study

SHAN GAO, MING LI, BCAMS GROUP

Diabetes 2023;72(Supplement_1):1099-P

https://doi.org/10.2337/db23-1099-P

Published: 20 June 2023

View article titled, 1099-P: Plasma Amino Acid Profiles in Childhood Predict 10-Year Risk of Insulin Resistance in Adulthood—The BCAMS Study

Meeting Abstracts

154-OR: Metabolomics Analysis Reveals Links between Stress Hyperglycemia and Underlying Differences in Branched-Chain Amino-Acid Metabolism and Microbiome–Host Interactions

AMALIA ABRAHAM, MATTHEW R. SMITH, MIREYA PEREZ-GUZMAN, FARBOD ZAHEDI TAJRISHI, LIZDA I. GUERRERO ARROYO, AMSHUMANTH CHAKRAGIRI, JITHIN SAM VARGHESE, FRANCISCO J. PASQUEL

Diabetes 2023;72(Supplement_1):154-OR

https://doi.org/10.2337/db23-154-OR

Published: 20 June 2023

View article titled, 154-OR: Metabolomics Analysis Reveals Links between Stress Hyperglycemia and Underlying Differences in Branched-Chain Amino-Acid Metabolism and Microbiome–Host Interactions

Meeting Abstracts

1581-P: Systemic Alteration of Amino Acids Metabolism in Glutamate Dehydrogenase Gain-of-Function Mutation Knockin Mice

CHANG SU, DONGNA HAN, SHI MENG, QIUSHA ZHU, XUE ZHOU, HAOWEN JIANG, JIA LI, CHUNXIU GONG, CHANGHONG LI

Diabetes 2023;72(Supplement_1):1581-P

https://doi.org/10.2337/db23-1581-P

Published: 20 June 2023

View article titled, 1581-P: Systemic Alteration of Amino Acids Metabolism in Glutamate Dehydrogenase Gain-of-Function Mutation Knockin Mice

Meeting Abstracts

1516-P: Free Fatty Acid and Amino Acid Predictors of Response to Metformin in Polycystic Ovary Syndrome

ALICE Y. CHANG, ANEESH K. ASOKAN, DHANANJAY SAKRIKAR, ANTIGONI LALIA, IAN R. LANZA, MAI PETTERSON, K. SREEKUMARAN NAIR

Diabetes 2023;72(Supplement_1):1516-P

https://doi.org/10.2337/db23-1516-P

Published: 20 June 2023

View article titled, 1516-P: Free Fatty Acid and Amino Acid Predictors of Response to Metformin in Polycystic Ovary Syndrome

Meeting Abstracts

739-P: Metabolome Alterations Associated with 12-Week Sitting Time Reduction among Sedentary, Postmenopausal Latinas

JEFFREY PATTERSON, PANIZ JASBI, HAIWEI GU, MATTHEW ALLISON, CHASE REUTER, BRINDA RANA, LOKI NATARAJAN, DOROTHY D. SEARS

Diabetes 2023;72(Supplement_1):739-P

https://doi.org/10.2337/db23-739-P

Published: 20 June 2023

View article titled, 739-P: Metabolome Alterations Associated with 12-Week Sitting Time Reduction among Sedentary, Postmenopausal Latinas

Meeting Abstracts

230-LB: A Composite Capsule Strategy Support Longevity of Microencapsulated Pancreatic ß Cells

TIAN QIN, ALEXANDRA M. SMINK, PAUL DE VOS

Diabetes 2023;72(Supplement_1):230-LB

https://doi.org/10.2337/db23-230-LB

Published: 20 June 2023

View article titled, 230-LB: A Composite Capsule Strategy Support Longevity of Microencapsulated Pancreatic ß Cells

Journal Articles

Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study

Yeyi Zhu, Dinesh K. Barupal, Amanda L. Ngo, Charles P. Quesenberry, Juanran Feng, Oliver Fiehn, Assiamira Ferrara

Diabetes 2022;71(8):1807–1817

https://doi.org/10.2337/db21-1093

Published: 21 August 2022

View article titled, Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study

Journal Articles

The Effect of Glucagon on Protein Catabolism During Insulin Deficiency: Exchange of Amino Acids Across Skeletal Muscle and the Splanchnic Bed

Haleigh James, Wilson I. Gonsalves, Shankarappa Manjunatha, Surendra Dasari, Ian R. Lanza, Katherine A. Klaus, Adrian Vella, James C. Andrews, K. Sreekumaran Nair

Diabetes 2022;71(8):1636–1648

https://doi.org/10.2337/db22-0079

Published: 21 August 2022

View article titled, The Effect of Glucagon on Protein Catabolism During Insulin Deficiency: Exchange of Amino Acids Across Skeletal Muscle and the Splanchnic Bed

Journal Articles

The Liver–α-Cell Axis in Health and in Disease

Michael M. Richter, Katrine D. Galsgaard, Emilie Elmelund, Filip K. Knop, Malte P. Suppli, Jens J. Holst, Marie Winther-Sørensen, Sasha A.S. Kjeldsen, Nicolai J. Wewer Albrechtsen

Diabetes 2022;71(9):1852–1861

https://doi.org/10.2337/dbi22-0004

Published: 03 June 2022

View article titled, The Liver–α-Cell Axis in Health and in Disease

Meeting Abstracts

230-LB: Amino Acid–Induced Glucagon Secretion and Glucagon Enhancement of Amino Acid Catabolism Is Independent of Glucose

KATHARINA MARUSZCZAK, CHRISTINE RASMUSSEN, FREDERIK R. CEUTZ, ANNE ØRGAARD, EMILIE E. CHRISTENSEN, MICHAEL M. RICHTER, JENS J. HOLST, MARIE WINTHER-SOERENSEN, NICOLAI J. WEWER ALBRECHTSEN

Diabetes 2022;71(Supplement_1):230-LB

https://doi.org/10.2337/db22-230-LB

Published: 01 June 2022

View article titled, 230-LB: Amino Acid–Induced Glucagon Secretion and Glucagon Enhancement of Amino Acid Catabolism Is Independent of Glucose

Meeting Abstracts

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

HANNAH R. FOSTER, THUONG HO, EVGENIY POTAPENKO, REBECCA L. CARDONE, RICHARD KIBBEY, IV, MATTHEW J. MERRINS

Diabetes 2022;71(Supplement_1):316-OR

https://doi.org/10.2337/db22-316-OR

Published: 01 June 2022

View article titled, 316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

Meeting Abstracts

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

MARIA GALIPEAU, NATHALIE JOUVET, EMILIE COURTY, ROXANNE VANDENBEEK, NAVEEN P. KHAN, KHALIL BOUYAKDAN, CUILAN NIAN, CATERINA IORIO, DANIEL D. SCOTT, MAY FARAJ, MARLENE OEFFINGER, FRANCIS C. LYNN, ROBERT A. SCREATON, THIERRY ALQUIER, JENNIFER L. ESTALL

Diabetes 2022;71(Supplement_1):299-OR

https://doi.org/10.2337/db22-299-OR

Published: 01 June 2022

View article titled, 299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

Meeting Abstracts

214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

EMILIE E. CHRISTENSEN, KATRINE D. GALSGAARD, CHRISTIAN D. JOHANSEN, SAMUEL TRAMMELL, ANNA B. BOMHOLT, JENNA HUNT, THOMAS KRUSE, JESPER F. LAU, TRISHA GREVENGOED, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN

Diabetes 2022;71(Supplement_1):214-LB

https://doi.org/10.2337/db22-214-LB

Published: 01 June 2022

View article titled, 214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

Meeting Abstracts

275-OR: Inhibition of Hepatic ACC Decreases Ketogenesis during Fasting due to Elevated Amino Acid Availability

STANISLAW DEJA, JUSTIN A. FLETCHER, BLANKA KUCEJOVA, MONIKA N. MIZERSKA, XIAORONG FU, CHAI-WAN KIM, JEFFREY BROWNING, JAMEY YOUNG, JAY D. HORTON, SHAWN C. BURGESS

Diabetes 2022;71(Supplement_1):275-OR

https://doi.org/10.2337/db22-275-OR

Published: 01 June 2022

View article titled, 275-OR: Inhibition of Hepatic ACC Decreases Ketogenesis during Fasting due to Elevated Amino Acid Availability

Meeting Abstracts

498-P: Resistance Exercise Rapidly Alters Citric Acid Cycle and Amino Acid Metabolism in Skeletal Muscle

MARK W. PATAKY, ARATHI PRABHA KUMAR, KATHERINE KLAUS, K. SREEKUMARAN NAIR

Diabetes 2021;70(Supplement_1):498-P

https://doi.org/10.2337/db21-498-P

Published: 01 June 2021

View article titled, 498-P: Resistance Exercise Rapidly Alters Citric Acid Cycle and Amino Acid Metabolism in Skeletal Muscle

Meeting Abstracts

1216-P: Plasma Amino Acid Profile as a Predictive Biomarker for Visceral Adiposity in Japanese Americans

ANH TRAN, PANDORA WANDER, MELISSA K. THOMAS, STEVEN E. KAHN, WILFRED Y. FUJIMOTO, EDWARD J. BOYKO

Diabetes 2021;70(Supplement_1):1216-P

https://doi.org/10.2337/db21-1216-P

Published: 01 June 2021

View article titled, 1216-P: Plasma Amino Acid Profile as a Predictive Biomarker for Visceral Adiposity in Japanese Americans

Meeting Abstracts

186-OR: Risk Prediction of Early Decline in Renal Function in Diabetic Kidney Disease with Algorithm Including Fractional Excretion of Glycated Amino Acids

PAUL THORNALLEY, ALBERTO DE LA FUENTE, NAILA RABBANI

Diabetes 2021;70(Supplement_1):186-OR

https://doi.org/10.2337/db21-186-OR

Published: 01 June 2021

View article titled, 186-OR: Risk Prediction of Early Decline in Renal Function in Diabetic Kidney Disease with Algorithm Including Fractional Excretion of Glycated Amino Acids

Journal Articles

Adipose Tissue Lipokines: Recent Progress and Future Directions

Veronica L. Li, Joon T. Kim, Jonathan Z. Long

Diabetes 2020;69(12):2541–2548

https://doi.org/10.2337/dbi20-0012

Published: 16 November 2020

View article titled, Adipose Tissue Lipokines: Recent Progress and Future Directions

Journal Articles

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Åke Lernmark

Diabetes 2020;69(11):2523–2535

https://doi.org/10.2337/db20-0374

Published: 31 August 2020

View article titled, Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

NARROW

1601-P: Childhood Plasma Amino Acid Profiles Predict the 10-Year Risk of Nonalcoholic Fatty Liver Disease—The BCAMS Study

1099-P: Plasma Amino Acid Profiles in Childhood Predict 10-Year Risk of Insulin Resistance in Adulthood—The BCAMS Study

154-OR: Metabolomics Analysis Reveals Links between Stress Hyperglycemia and Underlying Differences in Branched-Chain Amino-Acid Metabolism and Microbiome–Host Interactions

1581-P: Systemic Alteration of Amino Acids Metabolism in Glutamate Dehydrogenase Gain-of-Function Mutation Knockin Mice

1516-P: Free Fatty Acid and Amino Acid Predictors of Response to Metformin in Polycystic Ovary Syndrome

739-P: Metabolome Alterations Associated with 12-Week Sitting Time Reduction among Sedentary, Postmenopausal Latinas

230-LB: A Composite Capsule Strategy Support Longevity of Microencapsulated Pancreatic ß Cells

Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study

The Effect of Glucagon on Protein Catabolism During Insulin Deficiency: Exchange of Amino Acids Across Skeletal Muscle and the Splanchnic Bed

The Liver–α-Cell Axis in Health and in Disease

230-LB: Amino Acid–Induced Glucagon Secretion and Glucagon Enhancement of Amino Acid Catabolism Is Independent of Glucose

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism

214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth

275-OR: Inhibition of Hepatic ACC Decreases Ketogenesis during Fasting due to Elevated Amino Acid Availability

498-P: Resistance Exercise Rapidly Alters Citric Acid Cycle and Amino Acid Metabolism in Skeletal Muscle

1216-P: Plasma Amino Acid Profile as a Predictive Biomarker for Visceral Adiposity in Japanese Americans

186-OR: Risk Prediction of Early Decline in Renal Function in Diabetic Kidney Disease with Algorithm Including Fractional Excretion of Glycated Amino Acids

Adipose Tissue Lipokines: Recent Progress and Future Directions

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes

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