On the cover: Primary rat islet cells immunostained for insulin (green), the exosome marker CD81 (red), trans Golgi marker TGN38 (magenta), and nuclei (blue) reveal colocalization of insulin and CD81 in a subgroup of insulin-positive vesicles budding off from the trans Golgi membranes. Image courtesy of Chiara Cianciaruso, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Her article, “Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity,” appears in this issue of Diabetes (p. 460).
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