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Editorial

Gestational Diabetes Mellitus: Primum Non Nocere

Shivani Misra, MRCP; Anne Dornhorst, FRCP

Extract

View articletitled, Gestational Diabetes Mellitus: Primum Non Nocere

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Topics: genes , gestational diabetes , hyperglycemia , maturity onset diabetes mellitus in young , mutation

Diabetes Care August 2012, Vol.35, 1811-1813. doi:https://doi.org/10.2337/dc12-0689

Commentary

Severe Hypoglycemia Predicts Mortality in Diabetes

Philip E. Cryer, MD

Extract

View articletitled, Severe Hypoglycemia Predicts Mortality in Diabetes

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Topics: hypoglycemia

Diabetes Care August 2012, Vol.35, 1814-1816. doi:https://doi.org/10.2337/dc12-0749

Original Research

Clinical Care / Education / Nutrition / Psychosocial Research

Administration of CD4⁺CD25^highCD127⁻ Regulatory T Cells Preserves β-Cell Function in Type 1 Diabetes in Children

Natalia Marek-Trzonkowska, VMD; MaŁgorzata Myśliwiec, MD; Anita Dobyszuk, MSC; Marcelina Grabowska, MSC; Ilona Techmańska, MD; Jolanta Juścińska, MD; Magdalena A. Wujtewicz, MD; Piotr Witkowski, MD; Wojciech Młynarski, MD; Anna Balcerska, MD, PHD; Jolanta Myśliwska, MD; Piotr Trzonkowski, MD

Abstracts

View articletitled, Administration of CD4+CD25highCD127− Regulatory T Cells Preserves β-Cell Function in Type 1 Diabetes in Children

Supplementary data

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Topics: antigens, cd25 , child , diabetes mellitus, type 1 , insulin , interleukin 7 receptor

Diabetes Care August 2012, Vol.35, 1817-1820. doi:https://doi.org/10.2337/dc12-0038

Performance of HbA_1c as an Early Diagnostic Indicator of Type 1 Diabetes in Children and Youth

Kendra Vehik, PHD; David Cuthbertson, MS; David Boulware, MS; Craig A. Beam, PHD; Henry Rodriguez, MD; Laurent Legault, MD; Mila Hyytinen, PHD; Marian J. Rewers, MD; Desmond A. Schatz, MD; Jeffrey P. Krischer, PHD; the TEDDY, TRIGR, Diabetes Prevention Trial–Type 1, and Type 1 Diabetes TrialNet Natural History Study Groups

Abstracts

View articletitled, Performance of HbA1c as an Early Diagnostic Indicator of Type 1 Diabetes in Children and Youth

Supplementary data

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Topics: hemoglobin a, glycosylated , oral glucose tolerance test , diphtheria-tetanus-pertussis vaccine , diabetes mellitus, type 1

Diabetes Care August 2012, Vol.35, 1821-1825. doi:https://doi.org/10.2337/dc12-0111

Indexing Severity of Diabetic Foot Infection With ^99mTc-WBC SPECT/CT Hybrid Imaging

William A. Erdman, MD; Ji Buethe, MD; Rafia Bhore, PHD; Hans K. Ghayee, DO; Chiarra Thompson, MD; Param Maewal, MD; Jon Anderson, PHD; Steve Klemow, MD; Orhan K. Oz, MD

Abstract

View articletitled, Indexing Severity of Diabetic Foot Infection With 99mTc-WBC SPECT/CT Hybrid Imaging

Supplementary data

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Topics: antibiotic therapy , diabetic foot ulcer , diagnostic imaging , osteomyelitis , spect ct scans

Diabetes Care August 2012, Vol.35, 1826-1831. doi:https://doi.org/10.2337/dc11-2425

Antenatal Diagnosis of Fetal Genotype Determines if Maternal Hyperglycemia Due to a Glucokinase Mutation Requires Treatment

Ali J. Chakera, MBCHB; Victoria L. Carleton, MBBS; Sian Ellard, PHD; Jencia Wong, PHD; Dennis K. Yue, PHD; Jason Pinner, MBBS; Andrew T. Hattersley, DM; Glynis P. Ross, MBBS

Abstracts

View articletitled, Antenatal Diagnosis of Fetal Genotype Determines if Maternal Hyperglycemia Due to a Glucokinase Mutation Requires Treatment

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Topics: fetus , genotype , glucokinase , hyperglycemia , mutation

Diabetes Care August 2012, Vol.35, 1832-1834. doi:https://doi.org/10.2337/dc12-0151

Epidemiology / Health Services Research

Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults

Peter T. Campbell, PHD; Christina C. Newton, MSPH; Alpa V. Patel, PHD; Eric J. Jacobs, PHD; Susan M. Gapstur, PHD

Abstracts

View articletitled, Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults

Supplementary data

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Topics: body mass index procedure , breast , cancer , cerebrovascular accident , follow-up

Diabetes Care August 2012, Vol.35, 1835-1844. doi:https://doi.org/10.2337/dc12-0002

Association of Prediabetes and Diabetes With Stroke Symptoms : The REasons for Geographic And Racial Differences in Stroke (REGARDS) study *

April P. Carson, PHD; Paul Muntner, PHD; Brett M. Kissela, MD; Dawn O. Kleindorfer, MD; Virginia J. Howard, PHD; James F. Meschia, MD; Linda S. Williams, MD; Ronald J. Prineas, MD; George Howard, DRPH; Monika M. Safford, MD

Abstracts

View articletitled, Association of Prediabetes and Diabetes With Stroke Symptoms : The REasons for Geographic And Racial Differences in Stroke (REGARDS) study<a href="javascript:;" reveal-id="fn2" data-open="fn2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">*</a>

Supplementary data

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Topics: cerebrovascular accident , ischemic stroke , prediabetes

Diabetes Care August 2012, Vol.35, 1845-1852. doi:https://doi.org/10.2337/dc11-2140

Fasting Insulin Levels and Metabolic Risk Factors in Type 2 Diabetic Patients at the First Visit in Japan: A 10-year, nationwide, observational study (JDDM 28)

Ikuro Matsuba, MD; Kazumi Saito, MD; Masahiko Takai, MD; Koichi Hirao, MD; Hirohito Sone, MD; on behalf of the Japan Diabetes Clinical Data Management Study Group

Abstract

View articletitled, Fasting Insulin Levels and Metabolic Risk Factors in Type 2 Diabetic Patients at the First Visit in Japan: A 10-year, nationwide, observational study (JDDM 28)

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Topics: cardiometabolic risk factors , insulin , overnight fasting insulin measurement , body mass index procedure , diabetes mellitus, type 2

Diabetes Care August 2012, Vol.35, 1853-1857. doi:https://doi.org/10.2337/dc12-0156

Adiponectin and All-Cause Mortality in Elderly People With Type 2 Diabetes

Jessica R. Singer, MD; Walter Palmas, MD; Jeanne Teresi, PHD; Ruth Weinstock, MD; Steven Shea, MD; José A. Luchsinger, MD

Abstracts

View articletitled, Adiponectin and All-Cause Mortality in Elderly People With Type 2 Diabetes

Supplementary data

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Topics: adiponectin , diabetes mellitus, type 2 , older adult

Diabetes Care August 2012, Vol.35, 1858-1863. doi:https://doi.org/10.2337/dc11-2215

The C Allele of ATM rs11212617 Does Not Associate With Metformin Response in the Diabetes Prevention Program

Jose C. Florez, MD; Kathleen A. Jablonski, PHD; Andrew Taylor, BA; Kieren Mather, MD; Edward Horton, MD; Neil H. White, MD; Elizabeth Barrett-Connor, MD; William C. Knowler, MD; Alan R. Shuldiner, MD; Toni I. Pollin, PHD; for the Diabetes Prevention Program Research Group

Abstracts

View articletitled, The C Allele of ATM rs11212617 Does Not Associate With Metformin Response in the Diabetes Prevention Program

Supplementary data

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Topics: alleles , diabetes prevention , metformin , diabetes mellitus, type 2

Diabetes Care August 2012, Vol.35, 1864-1867. doi:https://doi.org/10.2337/dc11-2301

Time-Dependent Impact of Diabetes on Mortality in Patients With Stroke: Survival up to 5 years in a health insurance population cohort in Germany

Andrea Icks, MD; Heiner Claessen, PHD; Stephan Morbach, MD; Gerd Glaeske, PHD; Falk Hoffmann, PHD

Abstract

View articletitled, Time-Dependent Impact of Diabetes on Mortality in Patients With Stroke: Survival up to 5 years in a health insurance population cohort in Germany

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Topics: cerebrovascular accident , ischemic stroke , germany

Diabetes Care August 2012, Vol.35, 1868-1875. doi:https://doi.org/10.2337/dc11-2159

Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity

Barbara J. Jefferis, MSC; Peter H. Whincup, PHD; Lucy Lennon, MSC; S. Goya Wannamethee, PHD

Abstract

View articletitled, Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity

Supplementary data

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Topics: body mass index procedure , diabetes mellitus, type 2 , obesity , insulin , waist circumference

Diabetes Care August 2012, Vol.35, 1876-1883. doi:https://doi.org/10.2337/dc11-2280

Newborn Size and Body Composition as Predictors of Insulin Resistance and Diabetes in the Parents: Parthenon Birth Cohort Study, Mysore, India

Sargoor R. Veena, MBBS; Ghattu V. Krishnaveni, PHD; Caroline H. Fall, DM

Abstract

View articletitled, Newborn Size and Body Composition as Predictors of Insulin Resistance and Diabetes in the Parents: Parthenon Birth Cohort Study, Mysore, India

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Topics: birth weight , insulin resistance , newborn , pregnancy , insulin

Diabetes Care August 2012, Vol.35, 1884-1890. doi:https://doi.org/10.2337/dc12-0177

Postchallenge Hyperglycemia Is Positively Associated With Diabetic Polyneuropathy: The KORA F4 study

Brenda W.C. Bongaerts, PHD; Wolfgang Rathmann, MD; Bernd Kowall, PHD; Christian Herder, PHD; Doris Stöckl, MD; Christa Meisinger, MD; Dan Ziegler, MD

Abstracts

View articletitled, Postchallenge Hyperglycemia Is Positively Associated With Diabetic Polyneuropathy: The KORA F4 study

Supplementary data

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Topics: deuterium , diabetic polyneuropathies , fasting blood glucose measurement , glucose , hemoglobin a, glycosylated

Diabetes Care August 2012, Vol.35, 1891-1893. doi:https://doi.org/10.2337/dc11-2028

Screening and Diagnosis of Gestational Diabetes Mellitus: Critical appraisal of the new International Association of Diabetes in Pregnancy Study Group recommendations on a national level

Ofra Kalter-Leibovici, MD; Laurence S. Freedman, PHD; Liraz Olmer, MA; Nicky Liebermann, MD; Anthony Heymann, MD; Orna Tal, MD; Liat Lerner-Geva, PHD; Nir Melamed, MD; Moshe Hod, MD

Abstracts

View articletitled, Screening and Diagnosis of Gestational Diabetes Mellitus: Critical appraisal of the new International Association of Diabetes in Pregnancy Study Group recommendations on a national level

Supplementary data

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Topics: diabetes, during pregnancy , gestational diabetes , international association of diabetes and pregnancy study groups , screening , adverse pregnancy outcome

Diabetes Care August 2012, Vol.35, 1894-1896. doi:https://doi.org/10.2337/dc12-0041

Pathophysiology / Complications

Increased Mortality of Patients With Diabetes Reporting Severe Hypoglycemia

Rozalina G. McCoy, MD; Holly K. Van Houten, BA; Jeanette Y. Ziegenfuss, PHD; Nilay D. Shah, PHD; Robert A. Wermers, MD; Steven A. Smith, MD

Abstracts

View articletitled, Increased Mortality of Patients With Diabetes Reporting Severe Hypoglycemia

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Topics: hypoglycemia

Diabetes Care August 2012, Vol.35, 1897-1901. doi:https://doi.org/10.2337/dc11-2054

Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes

Pascaline Priou, MD; Marc Le Vaillant, PHD; Nicole Meslier, MD; Sylvaine Chollet, MD; Philippe Masson, MD; Marie P. Humeau, MD; Thierry Pigeanne, MD; Acya Bizieux-Thaminy, MD; François Goupil, MD; Frédéric Gagnadoux, MD; The IRSR Sleep Cohort Group

Abstracts

View articletitled, Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes

Supplementary data

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Topics: apnea-hypopnea index procedure , cardiovascular diseases , hemoglobin , hemoglobin a, glycosylated , obstructive sleep apnea

Diabetes Care August 2012, Vol.35, 1902-1906. doi:https://doi.org/10.2337/dc11-2538

The Relationship Between Brain Volume and Walking Outcomes in Older Adults With and Without Diabetic Peripheral Neuropathy

Brad Manor, PHD; Elizabeth Newton, PHD; Amir Abduljalil, PHD; Vera Novak, MD

Abstracts

View articletitled, The Relationship Between Brain Volume and Walking Outcomes in Older Adults With and Without Diabetic Peripheral Neuropathy

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Topics: diabetic neuropathies , diencephalon , foot , gait , older adult

Diabetes Care August 2012, Vol.35, 1907-1912. doi:https://doi.org/10.2337/dc11-2463

Cutaneous Structural and Biochemical Correlates of Foot Complications in High-Risk Diabetes

Abd A. Tahrani, MD; Wei Zeng, PHD; Jayadave Shakher, FRCP; Milan K. Piya, MRCP; Sharon Hughes, PHD; Kiran Dubb, MSC; Martin J. Stevens, MD

Abstract

View articletitled, Cutaneous Structural and Biochemical Correlates of Foot Complications in High-Risk Diabetes

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Topics: diabetic foot ulcer , foot , procollagen , skin , nerve fibers

Diabetes Care August 2012, Vol.35, 1913-1918. doi:https://doi.org/10.2337/dc11-2076

Circulating Osteocalcin Level Is Not Associated With Incident Type 2 Diabetes in Middle-Aged Male Subjects: Mean 8.4-year retrospective follow-up study

You-Cheol Hwang, MD; Jae-Hwan Jee, MD; In-Kyung Jeong, MD; Kyu Jeung Ahn, MD; Ho Yeon Chung, MD; Moon-Kyu Lee, MD

Abstract

View articletitled, Circulating Osteocalcin Level Is Not Associated With Incident Type 2 Diabetes in Middle-Aged Male Subjects: Mean 8.4-year retrospective follow-up study

Supplementary data

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Topics: diabetes mellitus, type 2 , follow-up , osteocalcin , middle-aged adult

Diabetes Care August 2012, Vol.35, 1919-1924. doi:https://doi.org/10.2337/dc11-2471

Cardiovascular and Metabolic Risk

Glucose Response Curve and Type 2 Diabetes Risk in Latino Adolescents

Joon Young Kim, BS; Dawn K. Coletta, PHD; Lawrence J. Mandarino, PHD; Gabriel Q. Shaibi, PHD

Abstract

View articletitled, Glucose Response Curve and Type 2 Diabetes Risk in Latino Adolescents

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Topics: adolescent , diabetes mellitus, type 2 , glucose , oral glucose tolerance test , deuterium

Diabetes Care August 2012, Vol.35, 1925-1930. doi:https://doi.org/10.2337/dc11-2476

NH₂-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications Study: The role of tumor necrosis factor-α

Gabriella Gruden, PHD; Federica Barutta, PHD; Nish Chaturvedi, MRCP; Casper Schalkwijk, PHD; Coen D. Stehouwer, PHD; Silvia Pinach, MSC; Maria Manzo, BSC; Maria Loiacono, BSC; Marinella Tricarico, MD; Giulio Mengozzi, MD; Daniel R. Witte, PHD; John H. Fuller, FRCP; Paolo Cavallo Perin, MD; Graziella Bruno, MD

Abstract

View articletitled, NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications Study: The role of tumor necrosis factor-α

Supplementary data

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Topics: cardiovascular diseases , diabetes mellitus complications , microbiology procedures , natriuretic peptides , nt-probnp

Diabetes Care August 2012, Vol.35, 1931-1936. doi:https://doi.org/10.2337/dc12-0089

Childhood Nutrition in Predicting Metabolic Syndrome in Adults: The Cardiovascular Risk in Young Finns Study

Paula Jääskeläinen, BM; Costan G. Magnussen, PHD; Katja Pahkala, PHD; Vera Mikkilä, PHD; Mika Kähönen, MD; Matthew A. Sabin, MD; Mikael Fogelholm, SCD; Nina Hutri-Kähönen, MD; Leena Taittonen, MD; Risto Telama, PHD; Tomi Laitinen, MD; Eero Jokinen, MD; Terho Lehtimäki, MD; Jorma S.A. Viikari, MD; Olli T. Raitakari, MD; Markus Juonala, MD

Abstract

View articletitled, Childhood Nutrition in Predicting Metabolic Syndrome in Adults: The Cardiovascular Risk in Young Finns Study

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Topics: child , vegetables , metabolic syndrome x , life style

Diabetes Care August 2012, Vol.35, 1937-1943. doi:https://doi.org/10.2337/dc12-0019

Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes

Martin K. Rutter, MD; Joseph M. Massaro, PHD; Udo Hoffmann, MD; Christopher J. O’Donnell, MD; Caroline S. Fox, MD

Abstract

View articletitled, Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes

Supplementary data

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Topics: fasting blood glucose measurement , impaired fasting glucose , obesity , body mass index procedure , waist circumference

Diabetes Care August 2012, Vol.35, 1944-1950. doi:https://doi.org/10.2337/dc11-1950

Meta-analysis

Ethnic Differences in Weight Loss and Diabetes Remission After Bariatric Surgery: A meta-analysis

Wanda M. Admiraal, MD; Funda Celik, MD; Victor E. Gerdes, MD; Ramsey M. Dallal, MD; Joost B. Hoekstra, MD; Frits Holleman, MD

Abstract

View articletitled, Ethnic Differences in Weight Loss and Diabetes Remission After Bariatric Surgery: A meta-analysis

Supplementary data

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Topics: bariatric surgery , disease remission , weight reduction , surgical procedures, operative

Diabetes Care August 2012, Vol.35, 1951-1958. doi:https://doi.org/10.2337/dc12-0260

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: hawaii , hyperphagia , louisiana , obesity , ohio

Diabetes Care August 2012, Vol.35, 1959. doi:https://doi.org/10.2337/dc12-ie09

Online Letters: Observations

Characteristics and Outcomes of Subjects With Diabetic Foot Ulceration

Mussarat Riaz, FCPS; Zahid Miyan, MCPS; Syed Itaat Zaidi, FCPS; S. Faraz Danish Alvi, MBBS; Asher Fawwad, MPhil; Muhammad Yakoob Ahmadani, FCPS; Asim Bin Zafar, MCPS; Rayaz A. Malik, MBCHB, FRCP, PHD; Abdul Basit, FRCP

Extract

View articletitled, Characteristics and Outcomes of Subjects With Diabetic Foot Ulceration

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Topics: diabetic foot ulcer , foot ulcer , amputation

Diabetes Care August 2012, Vol.35, e63. doi:https://doi.org/10.2337/dc11-1906

Quality of Diabetes Care in Italy: Information From a Large Population-Based Multiregional Observatory (ARNO Diabetes)

Graziella Bruno, MD; Enzo Bonora, MD, PHD; Roberto Miccoli, MD, PHD; Olga Vaccaro, MD; Elisa Rossi, BS; Davide Bernardi, BS; Marisa De Rosa, PHARMAD; Giulio Marchesini, MD; for the SID-CINECA ARNO Working Group

Extract

View articletitled, Quality of Diabetes Care in Italy: Information From a Large Population-Based Multiregional Observatory (ARNO Diabetes)

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Topics: italy

Diabetes Care August 2012, Vol.35, e64. doi:https://doi.org/10.2337/dc12-0765

Pilot Studies of Wearable Outpatient Artificial Pancreas in Type 1 Diabetes

Claudio Cobelli, PHD; Eric Renard, PHD, MD; Boris P. Kovatchev, PHD; Patrick Keith-Hynes, PHD; Najib Ben Brahim, MSC; Jérôme Place, MSC; Simone Del Favero, PHD; Marc Breton, PHD; Anne Farret, MD, PHD; Daniela Bruttomesso, MD, PHD; Eyal Dassau, PHD; Howard Zisser, MD; Francis J. Doyle, III, PHD; Stephen D. Patek, PHD; Angelo Avogaro, MD, PHD

Abstracts

View articletitled, Pilot Studies of Wearable Outpatient Artificial Pancreas in Type 1 Diabetes

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Topics: artificial pancreas , diabetes mellitus, type 1 , outpatients , cell phones , telemonitoring

Diabetes Care August 2012, Vol.35, e65-e67. doi:https://doi.org/10.2337/dc12-0660

Online Letters: Comments and Responses

Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536–541

Anubhav Thukral, MD; Sujoy Ghosh, MD, DM, MRCP, MRCPS; Satinath Mukhurjee, MD, DM; Subhankar Chowdhury, MD, DM, DTM&H, MRCP

Extract

View articletitled, Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536–541

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Topics: insulin resistance , puberty

Diabetes Care August 2012, Vol.35, e68. doi:https://doi.org/10.2337/dc12-0615

Response to Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536–541

Alison N. Jeffery, PHD; Brad S. Metcalf, MSC; Joanne Hosking, PHD; Adam J. Streeter, MSC; Linda D. Voss, PHD; Terence J. Wilkin, MD

Extract

View articletitled, Response to Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536–541

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Topics: insulin resistance , puberty

Diabetes Care August 2012, Vol.35, e69. doi:https://doi.org/10.2337/dc12-0774

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Clinical Care / Education / Nutrition / Psychosocial Research

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