Twelve maturity-onset diabetic subjects were treated with chlorpropamide once daily, glibenclamide once daily, or glibenclamide twice daily in a crossover design study. Doses were increased until the fasting blood glucose concentrations became < 6 mmol/L (108 mg/dl), at which time the patients were admitted for a 24-h study period. There was little difference between the plasma glucose and insulin responses to chlorpropamide or glibenclamide given twice daily (mean doses 489 and 11 mg/day, respectively). When glibenclamide was given once daily (mean dose 9 mg/day), similar plasma glucose concentrations during the day were obtained with slightly higher plasma glucose concentrations during the night. Four patients had chlorpropamide-induced flushing with alcohol, and six patients had postprandial hypoglycemia on glibenclamide. Chlorpropamide once daily or glibenclamide twice daily are suitable for control based on fasting blood glucose measurements.
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Brief Communications|
March 01 1981
Comparison of Chlorpropamide and Glibenclamide Treatment of Maturity-onset Diabetes: Control Assessed by Fasting Plasma Glucose Concentrations
E A Ward;
E A Ward
Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road
Oxford 0X2 6HE
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D A Lang;
D A Lang
Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road
Oxford 0X2 6HE
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M R Phillips;
M R Phillips
Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road
Oxford 0X2 6HE
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R C Turner
R C Turner
Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road
Oxford 0X2 6HE
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Address reprint requests to R. C. Turner at: the above address.
Citation
E A Ward, D A Lang, M R Phillips, R C Turner; Comparison of Chlorpropamide and Glibenclamide Treatment of Maturity-onset Diabetes: Control Assessed by Fasting Plasma Glucose Concentrations. Diabetes Care 1 March 1981; 4 (2): 293–295. https://doi.org/10.2337/diacare.4.2.293
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