OBJECTIVE: To investigate plasma pancreastatin (a chromogranin A-derived peptide) and catecholamine levels (counterregulatory hormones) in subjects with gestational diabetes compared with normal pregnant subjects. RESEARCH DESIGN AND METHODS: Fasting blood samples were obtained from 11 normal pregnant and 12 nonobese gestational diabetic subjects at late pregnancy (30+/-1 weeks). Selection criteria were those recommended by the National Diabetes Data Group (modified from O'Sullivan original criteria). Plasma glucose, insulin, glucagon, pancreastatin-like, epinephrine, and norepinephrine were measured. RESULTS: Gestational diabetic subjects had significantly higher insulin levels than control pregnant subjects (18+/-1 vs. 15+/-1 microU/ml), whereas glucose and glucagon levels where comparable in the two groups. However, increased catecholamine levels (epinephrine and norepinephrine) were found in the gestational diabetic group. We also found increased pancreastatin-like levels in these patients compared with the pregnant control group (46+/-2 vs. 30+/-2 pmol/l). Actually, pancreastatin levels positively correlated with both epinephrine (r = 0.34) and norepinephrine (r = 0.80) levels. CONCLUSIONS: Catecholamine and pancreastatin-like levels were found elevated in gestational diabetic subjects. These counterregulatory hormones may play a role in the insulin resistance syndrome of gestational diabetes.
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November 01 1998
Increased plasma pancreastatin-like levels in gestational diabetes: correlation with catecholamine levels.
V Sánchez-Margalet;
V Sánchez-Margalet
Department of Clinical Biochemistry, University Hospital Virgen Macarena, Seville, Spain. vsandhez@asterix.cica.es
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J A Lobón;
J A Lobón
Department of Clinical Biochemistry, University Hospital Virgen Macarena, Seville, Spain. vsandhez@asterix.cica.es
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A González;
A González
Department of Clinical Biochemistry, University Hospital Virgen Macarena, Seville, Spain. vsandhez@asterix.cica.es
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M L Fernández-Soto;
M L Fernández-Soto
Department of Clinical Biochemistry, University Hospital Virgen Macarena, Seville, Spain. vsandhez@asterix.cica.es
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F Escobar-Jiménez;
F Escobar-Jiménez
Department of Clinical Biochemistry, University Hospital Virgen Macarena, Seville, Spain. vsandhez@asterix.cica.es
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R Goberna
R Goberna
Department of Clinical Biochemistry, University Hospital Virgen Macarena, Seville, Spain. vsandhez@asterix.cica.es
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Citation
V Sánchez-Margalet, J A Lobón, A González, M L Fernández-Soto, F Escobar-Jiménez, R Goberna; Increased plasma pancreastatin-like levels in gestational diabetes: correlation with catecholamine levels.. Diabetes Care 1 November 1998; 21 (11): 1951–1954. https://doi.org/10.2337/diacare.21.11.1951
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