The frequency of the dawn phenomenon has been studied in non-insulin-dependent diabetic (NIDDM) patients while they continued with their conventional therapy. Plasma glucose (PG) and immunoreactive insulin (IRI) were estimated hourly from 0300 to 0900 h in 19 NIDDM patients; 9 patients were treated by diet alone (group 1), and 10 patients were treated by diet and oral hypoglycemic agents (group 2). The dawn rise of plasma glucose was demonstrated in 17 (89.5%) of the 19 patients with mean ± SE plasma glucose at 0300 h of 7.0 ± 0.5 mM and at 0800 h of 8.4 ± 0.6 (P < .01). IRI in all patients rose from 14.7 ± 1.3 μU/ml at 0500 h to 18.1 ± 1.8 μU/ml at 0700 h (P < .05). The changes in IRI levels at any time from 0300 to 0800 h in groups 1 and 2 when considered separately were insignificant. Thus, the dawn phenomenon occurs commonly in NIDDM patients taking their conventional therapy.
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Original Articles|
July 01 1987
Dawn Phenomenon: Its Frequency in Non-Insulin-Dependent Diabetic Patients on Conventional Therapy
Jameel A Atiea, MRCP;
Jameel A Atiea, MRCP
Diabetic Unit, Department of Medicine, University Hospital of Wales
Heath Park, Cardiff, United Kingdom
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Robert R J Ryder, MRCP;
Robert R J Ryder, MRCP
Diabetic Unit, Department of Medicine, University Hospital of Wales
Heath Park, Cardiff, United Kingdom
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Jiten Vora, MRCP;
Jiten Vora, MRCP
Diabetic Unit, Department of Medicine, University Hospital of Wales
Heath Park, Cardiff, United Kingdom
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David R Owens, MD;
David R Owens, MD
Diabetic Unit, Department of Medicine, University Hospital of Wales
Heath Park, Cardiff, United Kingdom
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Stephen D Luzio, MSc;
Stephen D Luzio, MSc
Diabetic Unit, Department of Medicine, University Hospital of Wales
Heath Park, Cardiff, United Kingdom
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Sheila Williams, AIMLT;
Sheila Williams, AIMLT
Diabetic Unit, Department of Medicine, University Hospital of Wales
Heath Park, Cardiff, United Kingdom
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Tom M Hayes, FRCP
Tom M Hayes, FRCP
Diabetic Unit, Department of Medicine, University Hospital of Wales
Heath Park, Cardiff, United Kingdom
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Address correspondence and reprint requests to Jameel A. Atiea, MRCP, Diabetic Unit, Dept. of Medicine, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK.
Citation
Jameel A Atiea, Robert R J Ryder, Jiten Vora, David R Owens, Stephen D Luzio, Sheila Williams, Tom M Hayes; Dawn Phenomenon: Its Frequency in Non-Insulin-Dependent Diabetic Patients on Conventional Therapy. Diabetes Care 1 July 1987; 10 (4): 461–465. https://doi.org/10.2337/diacare.10.4.461
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